{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:51:30Z","timestamp":1778183490292,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Interferon\u2010beta (IFN\u03b2), the most widely prescribed medication for multiple sclerosis, is generally considered safe. Nevertheless, rare serious and\/or life\u2010threatening side effects have been reported such as thrombotic microangiopathy. A few mechanisms have been proposed to explain how interferon causes thrombotic microangiopathy, but immunological studies have been unable to pin this phenomenon down to a single pathophysiologic pathway. The aim of this article was to report a new mechanism explaining Interferon beta related thrombotic microangiopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report thrombotic microangiopathy in a 28\u2010year\u2010old male receiving interferon\u2010beta treatment for multiple sclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After three\u2009years of starting interferon beta therapy, the patient presented with malignant hypertension causing seizures, rapidly progressive renal failure requiring haemodialysis and haemolytic anaemia. Corticosteroid and plasma exchange sessions permitted haemolysis control. Nonetheless, the patient remained hemodialysis\u2010dependent. Exploration of the complement system found a complement factor I deficiency whose activity normalized at the control carried out after 2\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IFN\u03b2 treatment may cause complement factor I deficit, which can lead to thrombotic microangiopathy and severe renal failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15631","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T20:34:38Z","timestamp":1670531678000},"page":"1682-1685","source":"Crossref","is-referenced-by-count":8,"title":["Thrombotic microangiopathy due to acquired complement factor I deficiency in a male receiving interferon\u2010beta treatment for multiple sclerosis"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1281-8785","authenticated-orcid":false,"given":"Sanda","family":"Mrabet","sequence":"first","affiliation":[{"name":"Department of Nephrology, Dialysis, and Transplantation Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse, H\u00f4pital Sahloul  Sousse Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rihem","family":"Dahmane","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Transplantation Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse, H\u00f4pital Sahloul  Sousse Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boukadida","family":"Raja","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Transplantation Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse, H\u00f4pital Sahloul  Sousse Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Fradi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Transplantation Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse, H\u00f4pital Sahloul  Sousse Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narjess Ben","family":"Aicha","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Transplantation Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse, H\u00f4pital Sahloul  Sousse Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wissal","family":"Sahtout","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Transplantation Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse, H\u00f4pital Sahloul  Sousse Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awatef","family":"Azzabi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Transplantation Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse, H\u00f4pital Sahloul  Sousse Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosra","family":"Guedri","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Transplantation Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse, H\u00f4pital Sahloul  Sousse Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorsaf","family":"Zellama","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Transplantation Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse, H\u00f4pital Sahloul  Sousse Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdellatif","family":"Achour","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Transplantation Universit\u00e9 de Sousse, Facult\u00e9 de M\u00e9decine de Sousse, H\u00f4pital Sahloul  Sousse 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