{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:22:14Z","timestamp":1787170934287,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The study's aim is to compare current and new equations for estimating glomerular filtration rate (GFR) based on creatinine, cystatin C, \u03b2\u2010trace protein (BTP) and \u03b22 microglobulin (B2M) among patients undergoing major amputation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a secondary analysis of data from a prospective cohort study investigating patients undergoing nontraumatic lower extremity amputation. Estimated GFR (eGFR) was calculated using equations based on creatinine (eGFRcre[2009] and eGFRcre[2021]), cystatin C (eGFRcys), the combination of creatinine and cystatin C (eGFRcomb[2012] and eGFRcomb[2021]) or a panel of all 4 filtration markers (eGFRpanel). Primary outcome was changed in eGFR across amputation according to each equation. Two case studies of prior amputation with GFR measured by 99mTc\u2010DTPA clearance are described to illustrate the relative accuracies of each eGFR equation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Analysis of the primary outcome included 29 patients (median age 75\u2009years, 31% female). Amputation was associated with a significant decrease in creatinine concentration (\u22120.09\u2009mg\/dL,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.004), corresponding to a significant increase in eGFRcre[2009] (+6.1\u2009mL\/min,\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u00a00.006) and eGFRcre[2021] (+6.3\u2009mL\/min,\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u00a00.006). Change across amputation was not significant for cystatin C, BTP, B2M or equations incorporating these markers (all\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&gt;\u20090.05). In both case studies, eGFRcre[2021] yielded the largest positive bias, eGFRcys yielded the largest negative bias and eGFRcomb[2012] and eGFRcomb[2021] yielded the smallest absolute bias.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Creatinine\u2010based estimates were substantially higher than cystatin C\u2010based estimates before amputation and significantly increased across amputation. Estimates combining creatinine and cystatin were stable across amputation, while the addition of BTP and B2M is unlikely to be clinically relevant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcp.15639","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T08:54:47Z","timestamp":1670921687000},"page":"1789-1798","source":"Crossref","is-referenced-by-count":8,"title":["Estimated glomerular filtration rate based on creatinine, cystatin C, \u03b2\u2010trace protein and \u03b22 microglobulin in patients undergoing nontraumatic lower extremity amputation"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-9257","authenticated-orcid":false,"given":"Esben","family":"Iversen","sequence":"first","affiliation":[{"name":"Department of Clinical Research Copenhagen University Hospital Amager &amp; Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Byriel","family":"Walls","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology University of Copenhagen  Copenhagen Denmark"},{"name":"The Capital Region Pharmacy  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamarie","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Copenhagen University Hospital Amager &amp; Hvidovre  Hvidovre Denmark"},{"name":"Department of Drug Design and Pharmacology University of Copenhagen  Copenhagen Denmark"},{"name":"The Capital Region Pharmacy  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia S\u00f8e","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Copenhagen University Hospital Amager &amp; Hvidovre  Hvidovre Denmark"},{"name":"The Research Unit of Orthopedic Nursing, Department of Orthopedic Surgery Copenhagen University Hospital Amager &amp; Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kallemose","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Copenhagen University Hospital Amager &amp; Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aino","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Copenhagen University Hospital Amager &amp; Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke Lundsgaard","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Copenhagen University Hospital Amager &amp; Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3410-6068","authenticated-orcid":false,"given":"Anne Kathrine","family":"Bengaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Copenhagen University Hospital Amager &amp; Hvidovre  Hvidovre Denmark"},{"name":"The Capital Region Pharmacy  Herlev Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle Gybel","family":"Juul\u2010Larsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Copenhagen University Hospital Amager &amp; Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Born\u00e6s","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Copenhagen University Hospital Amager &amp; Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Damgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical 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