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We present a narrative review of the published experimental studies, case reports and experts' opinions to support the effectiveness and safety of HDI in the treatment of CCB poisoning. Our review strongly encourages the use of HDI as first\u2010line therapy in CCB\u2010poisoned patients in the presence of cardiovascular compromise, especially if cardiac function impairment has been diagnosed, before, but without delaying, the administration of vasopressors\/inotropic drugs.<\/jats:p>","DOI":"10.1111\/bcp.15641","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T05:05:09Z","timestamp":1672981509000},"page":"1269-1274","source":"Crossref","is-referenced-by-count":13,"title":["High\u2010dose insulin should be used before vasopressors\/inotropes in calcium\u2010channel blocker toxicity"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2522-2764","authenticated-orcid":false,"given":"Bruno","family":"M\u00e9garbane","sequence":"first","affiliation":[{"name":"Department of Medical and Toxicological Critical Care Lariboisi\u00e8re Hospital  Paris France"},{"name":"Inserm UMRS 1144 University of Paris  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