{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:10:03Z","timestamp":1790554203925,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["72104003"],"award-info":[{"award-number":["72104003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Infections are common complications after stroke and associated with unfavourable outcomes. We aimed to evaluate the efficacy and safety of prophylactic antibiotics for post\u2010acute stroke infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed, Embase, the Cochrane Library, SinoMed, China National Knowledge Infrastructure, WanFang Data, China Science and Technology Journal Database, and clinical trial register platforms from inception to 15 February 2022. We included randomized clinical trials that evaluated the efficacy and safety of prophylactic antibiotics. Primary outcomes were mortality rate and incidence of pneumonia. The pooled risk ratio (RR) and mean differences with 95% confidence interval (CI) were calculated using the random or fixed\u2010effect model depending on heterogeneity. The quality of evidence was evaluated using the Grading of Recommendations, Assessment, Development and Evaluations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve studies (4809 participants) were included. There was no significant difference in the mortality rate (12 trials, <jats:italic>n<\/jats:italic>\u2009=\u20094740, RR 1.03 [95% Cl: 0.91\u20131.16], high\u2010quality evidence), incidence of pneumonia (7 trials, <jats:italic>n<\/jats:italic>\u2009=\u20094352, RR 0.94 [95% CI: 0.79\u20131.11], high\u2010quality evidence) and the incidence of adverse events between the prophylactic antibiotics and control groups. Prophylactic antibiotics significantly reduced the incidence of infections (8 trials, <jats:italic>n<\/jats:italic>\u2009=\u20094517, RR 0.72 [95% CI: 0.58\u20130.89], moderate\u2010quality evidence) and urinary tract infections (7 trials, <jats:italic>n<\/jats:italic>\u2009=\u20094352, RR 0.39 [95% CI: 0.3\u20130.49], moderate\u2010quality evidence). None of the subgroup analyses showed a significant difference in mortality or the incidence of pneumonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For acute stroke patients, prophylactic antibiotics were significantly associated with fewer incidences of any infections and urinary tract infections without significant differences in mortality rate and pneumonia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15646","type":"journal-article","created":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T07:09:00Z","timestamp":1671260940000},"page":"946-955","source":"Crossref","is-referenced-by-count":6,"title":["The efficacy and safety of prophylactic antibiotics for post\u2010acute stroke infection: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1110-9477","authenticated-orcid":false,"given":"Qing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of 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