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Growing data support their use as an adjuvant treatment option for other pituitary tumours including growth hormone, adrenocorticotrophic hormones, thyroid hormone secreting adenomas and nonfunctional pituitary tumours, all of which have been shown to express D2 receptors as well, albeit to varying extents. For those pituitary tumours inadequately treated by dopamine agonist alone, combined agonism of D2 and somatostatin receptors represent a new frontier in clinical development. Here we review the development and role of dopamine agonist for the treatment of prolactinomas, the literature supporting their adjuvant use for the treatment of all other pituitary tumours, and recent progress in the development of the next generation of chimeric compounds that target D2 and other receptor subtypes highly expressed on pituitary tumour cells.<\/jats:p>","DOI":"10.1111\/bcp.15660","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T16:54:36Z","timestamp":1673456076000},"page":"1304-1317","source":"Crossref","is-referenced-by-count":10,"title":["Dopamine agonists for the treatment of pituitary tumours: From ergot extracts to next generation therapies"],"prefix":"10.1111","volume":"89","author":[{"given":"Tamara L.","family":"Wexler","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine NYU Grossman School of Medicine  New York NY USA"},{"name":"Department of Medicine Perelman School of Medicine, University of 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