{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:54:48Z","timestamp":1791482088172,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000691","name":"Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Serum microRNA\u2010122 (miR\u2010122) is a novel biomarker for drug\u2010induced liver injury, with good sensitivity in the early diagnosis of paracetamol\u2010induced liver injury. We describe miR\u2010122 concentrations in participants with antituberculosis drug\u2010induced liver injury (AT\u2010DILI). We explored the relationship between miR\u2010122 and alanine aminotransferase (ALT) concentrations and the effect of N\u2010acetylcysteine (NAC) on miR\u2010122 concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included participants from a randomized placebo\u2010controlled trial of intravenous NAC in AT\u2010DILI. ALT and miR\u2010122 concentrations were quantified before and after infusion of NAC\/placebo. We assessed correlations between ALT and miR\u2010122 concentrations and described changes in ALT and miR\u2010122 concentrations between sampling occasions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 45 participants; mean age (\u00b1\u2009standard deviation) 38 (\u00b110) years, 58% female and 91% HIV positive. The median (interquartile range) time between pre\u2010 and post\u2010infusion biomarker specimens was 68\u2009h (47\u201077\u2009h). The median pre\u2010infusion ALT and miR\u2010122 concentrations were 420\u2009U\/L (238\u2010580) and 0.58 pM (0.18\u20101.47), respectively. Pre\u2010infusion ALT and miR\u2010122 concentrations were correlated (Spearman's \u03c1\u00a0=\u2009.54, <jats:italic>P<\/jats:italic>\u00a0=\u2009.0001). Median fold\u2010changes in ALT and miR\u2010122 concentrations between sampling were 0.56 (0.43\u20100.69) and 0.75 (0.23\u20101.53), respectively, and were similar in the NAC and placebo groups (<jats:italic>P<\/jats:italic>\u00a0=\u2009.40 and <jats:italic>P<\/jats:italic>\u00a0=\u2009.68 respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>miR\u2010122 concentrations in our participants with AT\u2010DILI were considerably higher than previously reported in healthy volunteers and in patients on antituberculosis therapy without liver injury. We did not detect an effect of NAC on miR\u2010122 concentrations. Further research is needed to determine the utility of miR\u2010122 in the diagnosis and management of AT\u2010DILI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15661","type":"journal-article","created":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T01:13:47Z","timestamp":1673658827000},"page":"1844-1851","source":"Crossref","is-referenced-by-count":12,"title":["Analysis of serum microRNA\u2010122 in a randomized controlled trial of N\u2010acetylcysteine for treatment of antituberculosis drug\u2010induced liver injury"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4354-3817","authenticated-orcid":false,"given":"Muhammed Shiraz","family":"Moosa","sequence":"first","affiliation":[{"name":"New Somerset Hospital, Department of Medicine University of Cape Town  Cape Town South 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Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5024-3420","authenticated-orcid":false,"given":"Chandni","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0104-8992","authenticated-orcid":false,"given":"Eithne","family":"Costello","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8028-4282","authenticated-orcid":false,"given":"Dan","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and 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