{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:44:50Z","timestamp":1747183490578,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T00:00:00Z","timestamp":1676764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>A 53\u2010year\u2010old woman with a history of acute myeloid leukaemia received a second allogeneic haematopoietic stem cell transplant and was prescribed, among other medications, acyclovir and letermovir (480\u2010mg daily oral dose) for prophylaxis of, respectively, herpes simplex and cytomegalovirus infection. The patient was admitted in the intensive care unit for dyspnoea and oliguria. Laboratory investigations revealed acute kidney injury but also a severe and progressive lactic acidosis. Liver function tests were within normal range. The combination of lactic acidosis, hypoglycaemia and acylcarnitine profile in plasma raised the suspicion of mitochondrial toxicity. Letermovir therapy was interrupted, and determination of plasma letermovir pharmacokinetics revealed a prolonged terminal half\u2010life (38.7\u00a0h) that was not significantly influenced by continuous venovenous haemofiltration. Exploration for genetic polymorphisms revealed that the patient was <jats:italic>SLCO1B1<\/jats:italic>*5\/*15 (c.521T&gt;C homozygous carrier and c.388A&gt;G heterozygous carrier) with a predicted nonfunctional organic anion transporting polypeptide 1B1 protein. The relationship between letermovir accumulation and development of lactic acidosis requires further observations.<\/jats:p>","DOI":"10.1111\/bcp.15686","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T08:42:35Z","timestamp":1675759355000},"page":"1686-1689","source":"Crossref","is-referenced-by-count":2,"title":["Lactic acidosis after allogeneic haematopoietic stem cell transplantation potentially related to letermovir"],"prefix":"10.1111","volume":"89","author":[{"given":"B\u00e9r\u00e9nice","family":"Manczak","sequence":"first","affiliation":[{"name":"Department of Intensive Care Cliniques universitaires Saint\u2010Luc  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Cl\u00e9mence","family":"Verdier","sequence":"additional","affiliation":[{"name":"Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail)\u2010UMR_S 1085  Rennes France"},{"name":"FHU SUPORT  Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph P.","family":"Dewulf","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Department Cliniques universitaires Saint\u2010Luc  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0908-3629","authenticated-orcid":false,"given":"Florian","family":"Lemaitre","sequence":"additional","affiliation":[{"name":"Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail)\u2010UMR_S 1085  Rennes France"},{"name":"FHU SUPORT  Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Haufroid","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Department Cliniques universitaires Saint\u2010Luc  Brussels Belgium"},{"name":"Louvain Centre for Toxicology and Applied Pharmacology UCLouvain  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4409-3352","authenticated-orcid":false,"given":"Philippe","family":"Hantson","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Cliniques universitaires Saint\u2010Luc  Brussels Belgium"},{"name":"Louvain Centre for Toxicology and Applied Pharmacology UCLouvain  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13376"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13292"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1420"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00657-22"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/18755453MTE05NDYa1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piaa036"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2020.122399"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkab316"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1423"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.852"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.15686","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcp.15686","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.15686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T19:21:55Z","timestamp":1692300115000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.15686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,19]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/bcp.15686"],"URL":"https:\/\/doi.org\/10.1111\/bcp.15686","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"type":"print","value":"0306-5251"},{"type":"electronic","value":"1365-2125"}],"subject":[],"published":{"date-parts":[[2023,2,19]]}}}