{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:52:52Z","timestamp":1782895972898,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T00:00:00Z","timestamp":1677888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1A2C110097111"],"award-info":[{"award-number":["2020R1A2C110097111"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002551","name":"Seoul National University","doi-asserted-by":"publisher","award":["04\u20102019\u20100030"],"award-info":[{"award-number":["04\u20102019\u20100030"]}],"id":[{"id":"10.13039\/501100002551","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Few studies have quantified the impact of risk factors on GI complications in elderly nonsteroidal anti\u2010inflammatory drug (NSAID) users. This study aimed to develop and validate a risk prediction score for severe GI complications to identify high\u2010risk elderly patients using NSAID.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the following two Korean claims datasets: customized data with an enrolment period 2016\u20132017 for model development, and the sample data in 2019 for external validation. We conducted a nested case\u2013control study for model development and validation. NSAID users were identified as the elderly (\u226565\u2009years) who received NSAIDs for more than 30\u2009days. Serious GI complications were defined as hospitalizations or emergency department visits, with a main diagnosis of GI bleeding or perforation. We applied the logistic least absolute shrinkage and selection operator (LASSO) regression model for variable selection and model fitting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 8176 cases and 81\u2009760 controls with a 1:10 matched follow\u2010up period in the derivation cohort. In the external validation cohort, we identified 372 cases from 254\u2009551 patients. The risk predictors were high\u2010dose NSAIDs, nonselective NSAID, complicated GI ulcer history, male sex, concomitant gastroprotective agents, relevant co\u2010medications, severe renal disease and cirrhosis. Area under the receiver operating characteristic curve was 0.79 (95% confidence interval, 0.77\u20130.81) in the external validation dataset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prediction model may be a useful tool for reducing the risk of serious GI complications by identifying high\u2010risk elderly patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15696","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T08:54:40Z","timestamp":1676883280000},"page":"2216-2223","source":"Crossref","is-referenced-by-count":5,"title":["Derivation and validation of a risk prediction score for nonsteroidal anti\u2010inflammatory drug\u2010related serious gastrointestinal complications in the elderly"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8481-4367","authenticated-orcid":false,"given":"Suhyun","family":"Lee","sequence":"first","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University  1, Gwanak\u2010ro Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3626-3999","authenticated-orcid":false,"given":"Kyu\u2010Nam","family":"Heo","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University  1, Gwanak\u2010ro Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mee Yeon","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University  1, Gwanak\u2010ro Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Mi","family":"Ah","sequence":"additional","affiliation":[{"name":"College of Pharmacy Yeungnam University  Gyeongsan Gyeongbuk 38541 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaekyu","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy University of California, San Francisco  533 Parnassus Avenue, U585, Box 0622 San Francisco California 94143\u20100622 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2261-7330","authenticated-orcid":false,"given":"Ju\u2010Yeun","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University  1, Gwanak\u2010ro Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13370"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2020.08.004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010015\u20101038\u20103"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2018.11.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109343(97)00207\u20106"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010013\u20100817\u2010y"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40870"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.115"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264\u2010022\u201001150\u2010x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2019.34.e316"},{"key":"e_1_2_11_12_1","unstructured":"ATC\/DDD Index 2021. 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