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While there is some evidence to suggest that ILE may have a positive effect in cardiovascular system toxicity after accidental intravenous lipophilic local anaesthetic overdose, this cannot be extrapolated to cases of severe poisoning resulting from oral drug overdose. Treatment recommendations are based upon variable outcome animal studies and low\u2010level clinical evidence with a significant degree of positive reporting bias. Currently, there is a paucity of controlled clinical data to support ILE use to treat severe drug poisoning after oral overdose. ILE use should be limited to well\u2010designed, ethically approved, controlled clinical trials aimed at determining the true effectiveness of this therapy. This should replace the current scattergun clinical use in a multiplicity of poisoning scenarios and subsequent anecdotal reporting approach.<\/jats:p>","DOI":"10.1111\/bcp.15717","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T05:59:34Z","timestamp":1680674374000},"page":"1719-1723","source":"Crossref","is-referenced-by-count":5,"title":["Intravenous Lipid Emulsion does NOT have a role in severe poisoning: CON"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0310-3983","authenticated-orcid":false,"given":"Andis","family":"Graudins","sequence":"first","affiliation":[{"name":"Monash Toxicology Unit, Monash Emergency Medicine Service, Monash Dandenong Hospital Monash Health  Dandenong Victoria Australia"},{"name":"Department of Medicine, Clinical Sciences at Monash Health Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwee Min 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