{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:22:22Z","timestamp":1791570142868,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Detection and characterization of idiosyncratic drug\u2010induced liver injury (DILI) currently rely on standard liver tests, which are suboptimal in terms of specificity, sensitivity and prognosis. Therefore, DILI diagnosis can be delayed, with important consequences for the patient. In this study, we aimed to evaluate the potential of osteopontin, cytokeratin\u201018 (caspase\u2010cleaved: ccK18 and total: K18), \u03b1\u2010glutathione\u2010<jats:italic>S<\/jats:italic>\u2010transferase and microRNA\u2010122 as new DILI biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serial blood samples were collected from 32 DILI and 34 non\u2010DILI acute liver injury (ALI) cases and a single sample from 43 population controls without liver injury (HLC) and analysed using enzyme\u2010linked immunosorbent assay (ELISA) or single\u2010molecule arrays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All biomarkers differentiated DILI and ALI from HLC with an area under receiver operator characteristic curve (AUC) value of &gt;0.75 but were less efficient in distinguishing DILI from ALI, with ccK18 (0.79) and K18 (0.76) demonstrating highest potential. However, the AUC improved considerably (0.98) for ccK18 when comparing DILI and a subgroup of autoimmune hepatitis cases. Cytokeratin\u201018, microRNA\u2010122 and \u03b1\u2010glutathione\u2010<jats:italic>S<\/jats:italic>\u2010transferase correlated well with traditional transaminases, while osteopontin correlated most strongly with the international normalized ratio (INR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ccK18 appears promising in distinguishing DILI from autoimmune hepatitis but less so from other forms of acute liver injury. Osteopontin demonstrates prognostic potential with higher levels detected in more severe cases regardless of aetiology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15724","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T19:53:02Z","timestamp":1679773982000},"page":"2497-2507","source":"Crossref","is-referenced-by-count":23,"title":["Evaluation of diagnostic and prognostic candidate biomarkers in drug\u2010induced liver injury <i>vs<\/i>. other forms of acute liver damage"],"prefix":"10.1111","volume":"89","author":[{"given":"Alejandro","family":"Cueto\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"UGC de Aparato Digestivo, Servicio de Farmacolog\u00eda Cl\u00ednica, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga\u2010IBIMA Plataforma BIONAND, Hospital Universitario Virgen de la Victoria Universidad de M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Niu","sequence":"additional","affiliation":[{"name":"UGC de Aparato Digestivo, Servicio de Farmacolog\u00eda Cl\u00ednica, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga\u2010IBIMA Plataforma BIONAND, Hospital Universitario Virgen de la Victoria Universidad de M\u00e1laga  M\u00e1laga Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en red Enfermedades Hep\u00e1ticas y digestivas (Ciberehd)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael","family":"\u00c1lvarez\u2010\u00c1lvarez","sequence":"additional","affiliation":[{"name":"UGC de Aparato Digestivo, Servicio de Farmacolog\u00eda Cl\u00ednica, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga\u2010IBIMA Plataforma BIONAND, Hospital Universitario Virgen de la Victoria Universidad de M\u00e1laga  M\u00e1laga Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en red Enfermedades Hep\u00e1ticas y digestivas (Ciberehd)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara","family":"L\u00f3pez\u2010Longarela","sequence":"additional","affiliation":[{"name":"Destina Genomica S.L.  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