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This study aimed to evaluate dosing regimens for coadministration of daptomycin and ceftaroline in special populations including paediatrics, renally impaired (RI), obese and geriatrics that generate sufficient coverage against daptomycin\u2010resistant MRSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Physiologically based pharmacokinetic models were developed from pharmacokinetic studies of healthy adults, geriatric, paediatric, obese and RI patients. The predicted profiles were used to evaluate joint probability of target attainment (PTA), as well as tissue\u2010to\u2010plasma ratios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The adult dosing regimens of 6\u00a0mg\/kg every (q)24h or q48h daptomycin and 300\u2013600\u2009mg q12h ceftaroline fosamil by RI categories achieved \u226590% joint PTA when the minimum inhibitory concentrations in the combination are at or below 1 and 4\u00a0\u03bcg\/mL against MRSA. In paediatrics, wherein there is no recommended daptomycin dosing regimen for <jats:styled-content style=\"fixed-case\"><jats:italic>S.\u00a0aureus<\/jats:italic><\/jats:styled-content> bacteraemia, \u226590% joint PTA is achieved when the minimum inhibitory concentrations in the combination are up to 0.5 and 2\u00a0\u03bcg\/mL for standard paediatric dosing regimens of 7\u00a0mg\/kg q24h daptomycin and 12\u2009mg\/kg q8h ceftaroline fosamil. Model predicted tissue\u2010to\u2010plasma ratios of 0.3 and 0.7 in the skin and lung, respectively, for ceftaroline and 0.8 in the skin for daptomycin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our work illustrates how physiologically based pharmacokinetic modelling can inform appropriate dosing of adult and paediatric patients and thereby enable prediction of target attainment in the patients during multitherapies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15731","type":"journal-article","created":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T22:44:37Z","timestamp":1680475477000},"page":"2726-2738","source":"Crossref","is-referenced-by-count":17,"title":["Physiologically based pharmacokinetic modelling to inform combination dosing regimens of ceftaroline and daptomycin in special populations"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5555-8771","authenticated-orcid":false,"given":"Frederico Severino","family":"Martins","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences of Ribeir\u00e3o Preto Science  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-5701","authenticated-orcid":false,"given":"Jos\u00e9 Eduardo Severino","family":"Martins","sequence":"additional","affiliation":[{"name":"Empresa Brasileira de Hemoderivados e Biotecnologia  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6527-6612","authenticated-orcid":false,"given":"Patricia","family":"Severino","sequence":"additional","affiliation":[{"name":"Technology and Research Institute (ITP) Tiradentes University (UNIT)  Aracaju Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-7351","authenticated-orcid":false,"given":"Pieter","family":"Annaert","sequence":"additional","affiliation":[{"name":"Drug Delivery and Disposition KU Leuven Department of Pharmaceutical and Pharmacological Sciences  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6405-9130","authenticated-orcid":false,"given":"Sherwin K. 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