{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:09:53Z","timestamp":1790201393394,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T00:00:00Z","timestamp":1681776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Paracetamol is commonly consumed by pregnant women, even though recent data have questioned its safety. Having chronic medical diseases (CMDs) may influence the prevalence of use during pregnancy. We aimed to assess the prevalence and patterns of use 3\u2009months prior to pregnancy and in the first trimester among women with and without CMDs and the potential influence of CMDs on frequent use in the first trimester.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used patient\u2010reported data from the Copenhagen Pregnancy Cohort from 1 October 2013 to 23 May 2019 with information on CMDs and paracetamol use. Prevalence and patterns of use were assessed descriptively and by multivariable logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 24\u2009019 pregnancies. Use of paracetamol prior to and in early pregnancy was significantly higher among women with CMDs compared to women without (40.7% <jats:italic>vs<\/jats:italic>. 35.8% and 9.1% <jats:italic>vs<\/jats:italic>. 5.1%, respectively). Women with CMDs were 2.7 times more likely to have a frequent intake compared to women without [aOR 2.69 (95% CI 2.05\u20133.32)]. Migraine, rheumatoid arthritis and mental disease were associated with a higher use of paracetamol [aOR 4.39 (3.20\u20136.02), aOR 4.32 (2.41\u20137.72) and aOR 2.74 (1.67\u20134.49), respectively].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with CMDs had a higher paracetamol use before and during pregnancy than women without CMDs. Women with migraine, rheumatoid arthritis and mental disease showed the highest risk of frequent use. This study highlights the importance of discussing pain relief in pregnancy and evaluating the influence of maternal CMDs when assessing adverse effects of paracetamol use during pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15732","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T04:24:43Z","timestamp":1680668683000},"page":"2582-2591","source":"Crossref","is-referenced-by-count":12,"title":["Paracetamol use prior to and in early pregnancy: Prevalence and patterns among women with and without chronic medical diseases"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3119-017X","authenticated-orcid":false,"given":"Mille","family":"Taagaard","sequence":"first","affiliation":[{"name":"Department of Obstetrics, The Juliane Marie Centre Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Biochemistry Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Rode","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Obstetrics, Center for Fetal Medicine Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mie Gaarskj\u00e6r","family":"de Wolff","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Copenhagen University Hospital  Amager\u2013Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Damm","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The Juliane Marie Centre Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen 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Kristine","family":"Hegaard","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The Juliane Marie Centre Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Faculty of Health Sciences Copenhagen University  Copenhagen Denmark"},{"name":"The Interdisciplinary Research Unit of Women's, Children's and Families' Health, The Juliane Marie Centre Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2474-2677","authenticated-orcid":false,"given":"Ane Lille\u00f8re","family":"Rom","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The Juliane Marie Centre Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"The Interdisciplinary Research Unit of Women's, Children's and Families' Health, The Juliane Marie Centre Copenhagen University Hospital Rigshospitalet  Copenhagen 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