{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:44:55Z","timestamp":1747183495110,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>Bleomycin is an antibiotic with cytotoxic properties that is commonly used in combination regimens for the treatment of Hodgkin lymphoma. The inconsistency in the dosage nomenclature of bleomycin appears universally, which increases the risk of medication errors. However, to the best of our knowledge, no such cases have been reported. Herein, we present a rare case report of a medication error caused by a bleomycin overdose. At the third cycle of chemotherapy, a 25\u2010year\u2010old patient with stage II Hodgkin lymphoma received a 10 times higher dose of bleomycin (150 USP) than that usually used as part of the doxorubicin, bleomycin, vindesine and dacarbazine protocol (ABVD). After the medication error was discovered, the patient was immediately treated with intravenous rehydration and furosemide to promote drug clearance. Additionally, methylprednisone and acetylcysteine were administered to prevent lung injury. However, the patient developed slight nausea and mild rash, which gradually improved after treatment. After evaluation with positron emission spectrometry\u2010computed tomography (PET\u2010CT), the patient received four cycles of AVD chemotherapy. No other obvious abnormalities were observed during the treatment and 1\u2010year follow\u2010up period. Hence, the toxicities, clinical management and selection of further chemotherapy after bleomycin overdose in such cases deserved serious attention. More importantly, management measures after this error may be used as a reference in other hospitals.<\/jats:p>","DOI":"10.1111\/bcp.15744","type":"journal-article","created":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T04:11:05Z","timestamp":1681531865000},"page":"1811-1815","source":"Crossref","is-referenced-by-count":1,"title":["Bleomycin overdose in a patient with stage II Hodgkin lymphoma: A case report of a medication error"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6384-1304","authenticated-orcid":false,"given":"Zhang","family":"Jieting","sequence":"first","affiliation":[{"name":"The Department of Pharmacy Affiliated Qingdao Central Hospital of Qingdao University  Qing Dao China"},{"name":"The Department of Pharmacy Qingdao Cancer Hospital  Qing Dao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Shuyi","sequence":"additional","affiliation":[{"name":"The Department of Pharmacy Affiliated Qingdao Central Hospital of Qingdao University  Qing Dao China"},{"name":"The Department of Pharmacy Qingdao Cancer Hospital  Qing Dao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Xiaolin","sequence":"additional","affiliation":[{"name":"The Department of Pharmacy Affiliated Qingdao Central Hospital of Qingdao University  Qing Dao China"},{"name":"The Department of Pharmacy Qingdao Cancer Hospital  Qing Dao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Hai","sequence":"additional","affiliation":[{"name":"The Department of Pharmacy Affiliated Qingdao Central Hospital of Qingdao University  Qing Dao China"},{"name":"The Department of Pharmacy Qingdao Cancer Hospital  Qing Dao China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13297"},{"issue":"7299","key":"e_1_2_8_3_1","first-page":"1423","article-title":"Medical errors. Dosage nomenclature of bleomycin needs to be standardised to avoid errors","volume":"322","author":"Stefanou A","year":"2001","journal-title":"BMJ"},{"volume-title":"Bleomycin sulfate instruction","year":"2010","author":"US Food and Drug Adminstration","key":"e_1_2_8_4_1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.6.1629"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.2.470"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.8461"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2005.01.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2013.819974"},{"key":"e_1_2_8_10_1","first-page":"1","article-title":"Amelioration of bleomycin and methotrexate\u2010induced pulmonary toxicity by Serratiopeptidase and Fisetin","author":"Shahbaz M","year":"2020","journal-title":"Nutr Cancer"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010017\u20103521\u20100"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.86.5.723"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408648"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201001\u2010827246"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510093"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.15744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T09:53:03Z","timestamp":1722333183000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.15744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,8]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/bcp.15744"],"URL":"https:\/\/doi.org\/10.1111\/bcp.15744","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"type":"print","value":"0306-5251"},{"type":"electronic","value":"1365-2125"}],"subject":[],"published":{"date-parts":[[2023,5,8]]}}}