{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:11:19Z","timestamp":1790964679765,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Copper deficiency resulting from prescribing zinc in high doses is a rare but life\u2010changing diagnosis that is frequently overlooked. The aim of this study is to gauge how often zinc\u2010induced copper deficiency is missed, to raise awareness of the condition and to stress the need for guidelines for prescribing zinc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Suspected cases of zinc\u2010induced copper deficiency were retrospectively obtained by selecting those patients with hyperzincaemia and hypocupraemia from the database of the Scottish Trace Element Laboratory. Case records were reviewed to determine the validity of the suspected diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After exclusions, 23 instances of high serum zinc and low serum copper concentrations were found. A positive diagnosis of zinc\u2010induced copper deficiency was made in 14 patients, of which 7 (50%) were previously undiagnosed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum zinc and copper concentrations are rarely measured in patients prescribed zinc and so the vast majority of cases of zinc\u2010induced copper deficiency are likely to be undiagnosed. We recommend the current official advice on the dose and frequency of zinc administration is revised in order to limit, and potentially eradicate, the condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15749","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T02:19:35Z","timestamp":1681784375000},"page":"2825-2829","source":"Crossref","is-referenced-by-count":15,"title":["Iatrogenic copper deficiency: Risks and cautions with zinc prescribing"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2634-582X","authenticated-orcid":false,"given":"Andrew","family":"Duncan","sequence":"first","affiliation":[{"name":"Department of Immunological Research University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Morrison","sequence":"additional","affiliation":[{"name":"NHS Tayside Ninewells Hospital  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Bryson","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Biomedical Sciences Strathclyde University  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100609.2008.01050.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753\u20104887.1979.tb02221.x"},{"key":"e_1_2_10_4_1","first-page":"380","article-title":"Treatment of Wilson's disease with zinc: intestinal metallothionein induction","volume":"120","author":"Yuzbsiyan\u2010Gurkan V","year":"1992","journal-title":"J Lab Clin Med"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005\u20102795(77)90057\u20105"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/107.6.965"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000132644.52613.FA"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12020"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath\u20102014\u2010202837"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563215595429"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010006\u20100259\u2010z"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.12968\/denu.2012.39.8.575"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1258\/0004563041731556"},{"key":"e_1_2_10_14_1","first-page":"324","article-title":"Excess oral zinc in man lowers copper levels","volume":"37","author":"Pfeiffer CC","year":"1978","journal-title":"Fed Proc"},{"key":"e_1_2_10_15_1","unstructured":"Food Standards Agency. 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