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A sequential population pharmacokinetic pharmacodynamics (PKPD) analysis with non\u2010linear mixed effects modelling was performed. Allopurinol maintenance dose to achieve target SU was simulated based on the final PKPD model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A one\u2010compartment model with first\u2010order absorption and elimination best described the oxypurinol concentration\u2013time data. Inhibition of SU by oxypurinol was described with a direct inhibitory <jats:italic>E<\/jats:italic><jats:sub>max<\/jats:sub> model using steady\u2010state oxypurinol concentrations. Fat\u2010free body mass, estimated creatinine clearance and <jats:italic>SLC22A12<\/jats:italic> rs505802 genotype (0.32 per T allele, 95% CI 0.13, 0.55) were found to predict differences in oxypurinol clearance. Oxypurinol concentration required to inhibit 50% of xanthine dehydrogenase activity was affected by <jats:italic>PDZK1<\/jats:italic> rs12129861 genotype (\u22120.27 per A allele, 95% CI \u22120.38, \u22120.13). Most individuals with both <jats:italic>PDZK1<\/jats:italic> rs12129861 AA and <jats:italic>SLC22A12<\/jats:italic> rs505802 CC genotypes achieve target SU (with at least 75% success rate) with allopurinol below the maximum dose, regardless of renal function and body mass. In contrast, individuals with both <jats:italic>PDZK1<\/jats:italic> rs12129861 GG and <jats:italic>SLC22A12<\/jats:italic> rs505802 TT genotypes would require more than the maximum dose, thus requiring selection of alternative medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The proposed allopurinol dosing guide uses individuals' fat\u2010free mass, renal function and <jats:italic>SLC22A12<\/jats:italic> rs505802 and <jats:italic>PDZK1<\/jats:italic> rs12129861 genotypes to achieve target SU.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15792","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:33:31Z","timestamp":1684470811000},"page":"2964-2976","source":"Crossref","is-referenced-by-count":4,"title":["Population pharmacokinetics, pharmacodynamics and pharmacogenetics modelling of oxypurinol in Hmong adults with gout and\/or hyperuricemia"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5090-4153","authenticated-orcid":false,"given":"Ya\u2010Feng","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Pharmacology, College of Pharmacy University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Brundage","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Pharmacology, College of Pharmacy University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0613-5534","authenticated-orcid":false,"given":"Youssef M.","family":"Roman","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy &amp; Outcomes Science, School of Pharmacy Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen A.","family":"Culhane\u2010Pera","sequence":"additional","affiliation":[{"name":"Minnesota Community Care  St. Paul Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9541-7823","authenticated-orcid":false,"given":"Robert J.","family":"Straka","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Pharmacology, College of Pharmacy University of Minnesota  Minneapolis Minnesota 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