{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:29:28Z","timestamp":1790659768534,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005275","name":"Region Hovedstaden","doi-asserted-by":"publisher","award":["E\u201012825\u201001\u201012\u201001"],"award-info":[{"award-number":["E\u201012825\u201001\u201012\u201001"]}],"id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008397","name":"Velux Fonden","doi-asserted-by":"publisher","award":["00025835"],"award-info":[{"award-number":["00025835"]}],"id":[{"id":"10.13039\/100008397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      To provide\n                      <jats:italic>posthoc<\/jats:italic>\n                      analyses of a clinical trial that reported beneficial effects of medication reviews on health\u2010related quality of life. Specifically, to describe the medication changes with a focus on deprescribing and to explore patient\u2010 and medication\u2010related factors that may identify patients most likely to benefit from medication reviews.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Posthoc<\/jats:italic>\n                      analyses of data from a pragmatic, nonblinded, randomized clinical trial investigating a medication review intervention (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03911934\">NCT03911934<\/jats:ext-link>\n                      ) in 408 geriatric outpatients treated with \u22659 medicines.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the medication review group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009196), 26% of the medicines prescribed at baseline were discontinued with 82% still being discontinued after 13\u2009months. The most common reason for discontinuation was lack of indication (72% of discontinuations). The medicines most often discontinued in the medication review group compared with usual care included: metoclopramide (11\/15\u2009=\u200973% discontinued\n                      <jats:italic>vs<\/jats:italic>\n                      . 1\/12\u2009=\u20098% in usual care), acetylsalicylic acid (20\/48\u2009=\u200942%\n                      <jats:italic>vs<\/jats:italic>\n                      . 2\/47\u2009=\u20094%), simvastatin (18\/48\u2009=\u200938%\n                      <jats:italic>vs<\/jats:italic>\n                      . 2\/58\u2009=\u20093%), zopiclone (23\/59\u2009=\u200939%\n                      <jats:italic>vs<\/jats:italic>\n                      . 4\/54\u2009=\u20097%), quinine (9\/14\u2009=\u200964%\n                      <jats:italic>vs<\/jats:italic>\n                      . 6\/16\u2009=\u200938%), citalopram (4\/18\u2009=\u200922%\n                      <jats:italic>vs<\/jats:italic>\n                      . 0\/20\u2009=\u20090%) and tramadol (18\/37\u2009=\u200949%\n                      <jats:italic>vs<\/jats:italic>\n                      . 8\/30\u2009=\u200927%). Factors associated with number of deprescribed medicines included: number of prescribed medicines, Drug Burden Index, patient motivation for medicine changes, and prescriptions of metoclopramide, iron preparations, antidepressants other than selective serotonin reuptake inhibitors, nonsteroidal anti\u2010inflammatory drugs, or drugs for urinary incontinence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Physician\u2010led medication reviews resulted in persistent deprescribing of medicines in older polypharmacy patients treated with \u22659 medicines. Motivation for having their medicine changed, treatment with more medicines, and a higher burden of sedative and anticholinergic medicines characterized the patients most likely to benefit from physician\u2010led medication reviews.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcp.15805","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T05:25:54Z","timestamp":1685510754000},"page":"3291-3301","source":"Crossref","is-referenced-by-count":14,"title":["Medication changes implemented during medication reviews and factors related to deprescribing:\n                    <i>Posthoc<\/i>\n                    analyses of a randomized clinical trial in geriatric outpatients with polypharmacy"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2662-4519","authenticated-orcid":false,"given":"Jonatan","family":"Kornholt","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen 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