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Although reduced tissue drug accumulation is one of the key features of platinum (Pt) resistance, little is known about Pt distribution in human PM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed Pt levels of blood samples and surgically resected specimens from 25 PM patients who had received neoadjuvant Pt\u2010based chemotherapy (CHT). Pt levels and tissue distributions were measured by laser ablation\u2010inductively coupled plasma\u2010mass spectrometry and correlated with clinicopathological features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In surgically resected PM specimens, mean Pt levels of nontumourous (fibrotic) areas were significantly higher (<jats:italic>vs<\/jats:italic> tumourous regions, <jats:italic>P<\/jats:italic>\u2009=\u20090.0031). No major heterogeneity of Pt distribution was seen within the tumourous areas. Pt levels correlated neither with the microvessel area nor with apoptosis rate in the tumourous or nontumourous regions. A significant positive correlation was found between serum and both full tissue section and tumourous area mean Pt levels (<jats:italic>r<\/jats:italic>\u2009=\u20090.532, <jats:italic>P<\/jats:italic>\u2009=\u20090.006, 95% confidence interval [95% CI] 0.161\u20100.771 and <jats:italic>r<\/jats:italic>\u2009=\u20090.415, <jats:italic>P<\/jats:italic>\u2009=\u20090.039, 95% CI 0.011\u20100.702, respectively). Furthermore, a significant negative correlation was detected between serum Pt concentrations and elapsed time from the last cycle of CHT (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.474, <jats:italic>P<\/jats:italic>\u2009=\u20090.017, 95% CI \u22120.738\u2010\u22120.084). Serum Pt levels correlated negatively with overall survival (OS) (<jats:italic>P<\/jats:italic>\u2009=\u20090.029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There are major differences in drug distribution between tumourous and nontumourous areas of PM specimens. Serum Pt levels significantly correlate with full section and tumourous area average Pt levels, elapsed time from the last CHT cycle, and OS. Further studies investigating clinicopathological factors that modulate tissue Pt concentration and distribution are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15813","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T16:38:41Z","timestamp":1686069521000},"page":"3364-3374","source":"Crossref","is-referenced-by-count":4,"title":["Laser ablation\u2010inductively coupled plasma\u2010mass spectrometry analysis reveals differences in chemotherapeutic drug distribution in surgically resected pleural mesothelioma"],"prefix":"10.1111","volume":"89","author":[{"given":"Anna","family":"Tisza","sequence":"first","affiliation":[{"name":"Department of Tumor Biology National Kor\u00e1nyi Institute of Pulmonology  Budapest Hungary"},{"name":"Department of Pathology and Experimental Cancer Research Semmelweis University  Budapest 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