{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:21:45Z","timestamp":1788517305929,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Sevoflurane is an ether\u2010based inhalational anaesthetic that induces and maintains general anaesthesia. Our study aimed to detect sevoflurane\u2010induced nephrogenic diabetes insipidus using data mining algorithms (DMAs) and molecular docking. The FAERS database was analysed using OpenVigil 2.1 for disproportionality analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed FAERS data from 2004 to 2022 to determine the incidence of nephrogenic diabetes insipidus associated with sevoflurane. Reporting odds ratios (RORs) and proportional reporting ratios (PRRs) with 95% confidence intervals were calculated. We also used molecular docking with AutoDock Vina to examine sevoflurane's binding affinity to relevant receptors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 554 nephrogenic diabetes insipidus cases were reported in FAERS, of which 2.5% (14 cases) were associated with sevoflurane. Positive signals were observed for sevoflurane with ROR of 76.012 (95% CI: 44.67\u2013129.35) and PRR of 75.72 (\u03c7<jats:sup>2<\/jats:sup>: 934.688). Of the 14 cases, 50% required hospitalization, 14% resulted in death, and the remaining cases were categorized as other outcomes. Molecular docking analysis showed that sevoflurane exhibited high binding affinity towards AQP2 (4NEF) and AVPR2 (6U1N) with docking scores of \u22124.9 and \u22125.3, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sevoflurane use is significantly associated with the incidence of nephrogenic diabetes insipidus. Healthcare professionals should be cautious when using this medication and report any adverse events to regulatory agencies. Further research is needed to validate these findings and identify risk factors while performing statistical adjustments to prevent false\u2010positives. Clinical monitoring is crucial to validate potential adverse effects of sevoflurane.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15869","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T01:08:55Z","timestamp":1691111335000},"page":"1804-1810","source":"Crossref","is-referenced-by-count":10,"title":["Bioinformatics\u2010guided disproportionality analysis of sevoflurane\u2010induced nephrogenic diabetes insipidus using the FDA Adverse Event Reporting System database"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4086-4693","authenticated-orcid":false,"given":"Akhil T.","family":"Jacob","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice Oxbridge College of Pharmacy  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3518-2417","authenticated-orcid":false,"given":"Ankitha Hari","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Oxbridge College of Pharmacy  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6070-6733","authenticated-orcid":false,"given":"Gayethri","family":"Halivana","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Oxbridge College of Pharmacy  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8409-3491","authenticated-orcid":false,"given":"Lipin","family":"Lukose","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2081-6827","authenticated-orcid":false,"given":"Gouri","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy Ramaiah University of Applied Sciences  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1721-4553","authenticated-orcid":false,"given":"Viswam","family":"Subeesh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/08958378.2019.1698677"},{"key":"e_1_2_10_3_1","volume-title":"Sevoflurane. StatPearls","author":"Edgington TL","year":"2022"},{"key":"e_1_2_10_4_1","unstructured":"PubChem.Compound summary for CID 5206 sevoflurane.https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Sevoflurane. Accessed August 10 2023."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2018.09.006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem\u20102021\u20100566"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018\u2010199921060\u201000002"},{"key":"e_1_2_10_8_1","unstructured":"British National Formulary.Sevoflurane: side effects.2022.https:\/\/bnf.nice.org.uk\/drugs\/sevoflurane\/#side-effects. 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