{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:38:33Z","timestamp":1792193913800,"version":"4.4.0"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Finger\u2010prick sampling has emerged as an attractive tool for therapeutic drug monitoring and associated diagnostics. We aimed to validate the clinical performance of using two volumetric devices (Capitainer\u00ae qDBS and Mitra\u00ae) for monitoring tacrolimus, creatinine and haemoglobin in kidney transplant (KTx) recipients. Secondarily, we evaluated potential differences between finger\u2010prick sampling performed by healthcare professionals <jats:italic>vs<\/jats:italic>. self\u2010sampling, and differences between the two devices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared finger\u2010prick and venous sampling in three settings: microsampling performed by healthcare personnel, self\u2010sampling under supervision, unsupervised self\u2010sampling. The finger\u2010prick samples were analysed with adapted methods and results compared to routine method analysis of the venous blood samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five KTx recipients completed the main study and 12 KTx recipients completed a post hoc validation study. For tacrolimus measurements and predicted area under the curve, the proportions within \u00b120% difference were 79%\u201396% for Capitainer and 77%\u201395% for Mitra. For creatinine and haemoglobin, the proportions within \u00b115% were 92%\u2013100% and 93%\u2013100% for Capitainer and 79%\u201396% and 67%\u201392% for Mitra, respectively. Comparing sampling situations, the success rate was consistent for Capitainer (92%\u201396%), whereas Mitra showed 72%\u201388% and 52%\u201372% success rates with samples collected by healthcare personnel and the patients themselves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Capitainer and Mitra are technically feasible for measuring tacrolimus, creatinine and haemoglobin. In the context of self\u2010sampling, Capitainer maintained consistent sampling success and analytical quality. Implementing volumetric finger\u2010prick self\u2010sampling for the monitoring of tacrolimus, creatinine and haemoglobin may simplify and improve the follow\u2010up of KTx recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.15870","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T02:43:21Z","timestamp":1691117001000},"page":"3690-3701","source":"Crossref","is-referenced-by-count":22,"title":["Clinical performance of volumetric finger\u2010prick sampling for the monitoring of tacrolimus, creatinine and haemoglobin in kidney transplant recipients"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2649-4769","authenticated-orcid":false,"given":"Nils Tore","family":"Vethe","sequence":"first","affiliation":[{"name":"Department of Pharmacology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0628-1769","authenticated-orcid":false,"given":"Anders","family":"\u00c5sberg","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Oslo University Hospital  Oslo Norway"},{"name":"Department of Pharmacy University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders Mikal","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragnhild","family":"Heier Skauby","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stein","family":"Bergan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Oslo University Hospital  Oslo Norway"},{"name":"Department of Pharmacy University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Midtvedt","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010681"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000864"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000697"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000655"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15433"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2022.08.014"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14249"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13755"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2023.340797"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000539"},{"key":"e_1_2_10_12_1","unstructured":"European Medicines Agency (EMA).Guideline on bioanalytical method validation.www.ema.europa.eu\/en\/bioanalytical-method-validation-scientific-guideline. Accessed August 12 2023."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm\u20102019\u20101260"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000643"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000994"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.15870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T08:04:06Z","timestamp":1702109046000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.15870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,4]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/bcp.15870"],"URL":"https:\/\/doi.org\/10.1111\/bcp.15870","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,4]]}}}