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We report the case of a patient with EGFR\u2010mutated non\u2010small cell lung carcinoma treated with 80\u2009mg\/day of the TKI osimertinib who achieved partial response of the tumour, but was subsequently subjected to a double\u2010barrelled jejunostomy due to ileus. Due to the development of SBS after the bypass surgery, plasma concentrations of osimertinib were monitored using mass spectrometry. The therapeutic drug monitoring confirmed a malabsorption of osimertinib in the patient (108\u2009ng\/mL, which is below the 5th percentile of the expected plasma concentration) and was useful to guide adjustments of TKI dosing in order to achieve adequate blood levels (161\u2009ng\/mL after increase of the dose to 120\u2009mg\/day) in order to maintain tumour control.<\/jats:p>","DOI":"10.1111\/bcp.15924","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T12:36:58Z","timestamp":1696941418000},"page":"344-349","source":"Crossref","is-referenced-by-count":5,"title":["Therapeutic drug monitoring of osimertinib in non\u2010small cell lung cancer and short bowel syndrome: A case report"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2003-1886","authenticated-orcid":false,"given":"R\u00e9mi","family":"Longuesp\u00e9e","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology and 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