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The patient was a 6\u2010month\u2010old female with sepsis due to bloodstream infection to <jats:styled-content style=\"fixed-case\"><jats:italic>Stenotrophomonas maltophilia<\/jats:italic><\/jats:styled-content> following stem cell transplantation for severe combined immunodeficiency. CRRT was started on Day 2. Concentrations have been monitored using liquid chromatography\u2013tandem mass spectrometry. Treatment was given every 8\u00a0h with a 2\u00a0h infusion of 30\u20137,5\u00a0mg\/kg and did not reach pharmacokinetic\/pharmacodynamic targets. Total clearance was respectively 1.7 and 3.02\u2009L\/h, with CRRT clearance respectively 28.8%\u201360% for ceftazidime and 14%\u201333% for avibactam. Those clearances are higher than reported in adult literature leading to a risk of treatment failure and emerging resistance. This supports the benefit of monitoring antimicrobial therapy under CRRT and the necessity to assess higher dosing or continuous infusion of ceftazidime\u2010avibactam.<\/jats:p>","DOI":"10.1111\/bcp.15993","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T06:28:54Z","timestamp":1704436134000},"page":"890-894","source":"Crossref","is-referenced-by-count":9,"title":["Pharmacokinetic of ceftazidime\u2010avibactam in a critically ill patient under high\u2010volume continuous venovenous haemodiafiltration: A first paediatric case report"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2823-7080","authenticated-orcid":false,"given":"Charlotte","family":"Collignon","sequence":"first","affiliation":[{"name":"Pediatric Intensive Care Unit APHP University Hospital Necker\u2010Enfants Malades  Paris 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