{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:38:36Z","timestamp":1784741916921,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/00111"],"award-info":[{"award-number":["PI19\/00111"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to assess the frequency of dosing inconsistencies in prescription data and the effect of four dosing assumption strategies on adherence estimates for antipsychotic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort, which linked prescription and dispensing data of adult patients with \u22651 antipsychotic prescription between 2015\u20102016 and followed up until 2019, in Catalonia (Spain). Four strategies were proposed for selecting the recommended dosing in overlapping prescription periods for the same patient and antipsychotic drug: (i) the minimum dosing prescribed; (ii) the dose corresponding to the latest prescription issued; (iii) the highest dosing prescribed; and (iv) all doses included in the overlapped period. For each strategy, one treatment episode per patient was selected, and the Continuous Medication Availability measure was used to assess adherence. Descriptive statistics were used to describe results by strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 277\u2009324 prescriptions included, 76% overlapped with other prescriptions (40% with different recommended dosing instructions). The number and characteristics of patients and treatment episodes (18\u2009292, 18\u2009303, 18\u2009339 and 18\u2009536, respectively per strategy) were similar across strategies. Mean adherence was similar between strategies, ranging from 57 to 60%. However, the proportion of patients with adherence \u226590% was lower when selecting all doses (28%) compared with the other strategies (35%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the high prevalence of overlapping prescriptions, the strategies proposed did not show a major effect on the adherence estimates for antipsychotic treatment. Taking into consideration the particularities of antipsychotic prescription practices, selecting the highest dose in the overlapped period seemed to provide a more accurate adherence estimate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.16042","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T03:00:37Z","timestamp":1710817237000},"page":"1480-1492","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of adherence to antipsychotics: A real\u2010world data study using four different dosing assumptions"],"prefix":"10.1111","volume":"90","author":[{"given":"Marina","family":"Fuente\u2010Moreno","sequence":"first","affiliation":[{"name":"Health Technology Assessment in Primary Care and Mental Health (PRISMA) Research Group, Teaching, Research &amp; Innovation Unit, Parc Sanitari Sant Joan de D\u00e9u Institut de Recerca Sant Joan de D\u00e9u  Esplugues de Llobregat Spain"},{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona  Barcelona Spain"},{"name":"Red de Investigaci\u00f3n en Cronicidad, Atenci\u00f3n Primaria y Promoci\u00f3n de la Salud (RICAPPS)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3106-2242","authenticated-orcid":false,"given":"Alexandra L.","family":"Dima","sequence":"additional","affiliation":[{"name":"Health Technology Assessment in Primary Care and Mental Health (PRISMA) Research Group, Teaching, Research &amp; Innovation Unit, Parc Sanitari Sant Joan de D\u00e9u Institut de Recerca Sant Joan de D\u00e9u  Esplugues de Llobregat Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Rubio\u2010Valera","sequence":"additional","affiliation":[{"name":"Health Technology Assessment in Primary Care and Mental Health (PRISMA) Research Group, Teaching, Research &amp; Innovation Unit, Parc Sanitari Sant Joan de D\u00e9u Institut de Recerca Sant Joan de D\u00e9u  Esplugues de Llobregat Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Baladon","sequence":"additional","affiliation":[{"name":"Red de Investigaci\u00f3n en Cronicidad, Atenci\u00f3n Primaria y Promoci\u00f3n de la Salud (RICAPPS)  Madrid Spain"},{"name":"Parc Sanitari Sant Joan de D\u00e9u  Sant Boi de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Chavarria","sequence":"additional","affiliation":[{"name":"Red de Investigaci\u00f3n en Cronicidad, Atenci\u00f3n Primaria y Promoci\u00f3n de la Salud (RICAPPS)  Madrid Spain"},{"name":"Parc Sanitari Sant Joan de D\u00e9u  Sant Boi de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore Fabrizio","family":"Contaldo","sequence":"additional","affiliation":[{"name":"Parc Sanitari Sant Joan de D\u00e9u  Sant Boi de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Pe\u00f1a\u2010Salazar","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP)  Madrid Spain"},{"name":"Parc Sanitari Sant Joan de D\u00e9u  Sant Boi de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky","family":"Serra\u2010Sutton","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP)  Madrid Spain"},{"name":"Ag\u00e8ncia de Qualitat i Avaluaci\u00f3 Sanit\u00e0ries de Catalunya (AQuAS); Health Quality and Assessment Agency of Catalonia  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Hermida\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Unitat de Farm\u00e0cia. 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