{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:06:31Z","timestamp":1783649191963,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of the study is to report the clinical and pharmacological observations from a pregnant patient treated with erlotinib in the second and third trimesters of pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Maternal and neonatal blood levels and safety of erlotinib and its metabolites were evaluated. Child development was monitored for 6\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 31\u2010year\u2010old woman with stage IV lung adenocarcinoma with <jats:italic>EGFR<\/jats:italic> exon19 deletion began treatment with erlotinib 150\u2009mg\/day at 17\u2009weeks of gestation. Although foetal growth retardation and oligohydramnios were observed at several times during the pregnancy, treatment was continued due to the severity of the maternal presentation, with ongoing foetal monitoring. The foetus seemed to tolerate and recover well without specific interventions. A healthy baby boy was delivered at 37\u2009weeks gestation. The child grew and developed without any obvious issues. At last follow\u2010up, at age 6\u00a0years, he was attending school at a grade appropriate for his age without health or developmental problems. Blood levels of erlotinib were 397\u2013856\u2009ng\/mL at 18\u201337\u2009weeks of gestation and 1190\u2009ng\/mL at 8\u00a0weeks postpartum. The blood concentration ratios of OSI\u2010413\u2010to\u2010erlotinib ranged from 0.167 to 0.253 at 18\u201337\u2009weeks of gestation, excluding 24\u2009weeks, and 0.131 at 8\u00a0weeks postpartum. The maternal\u2010to\u2010foetal transfer rate of erlotinib, OSI\u2010420 and OSI\u2010413 were 24.5, 34.8 and 20.3%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Erlotinib use during the second and third trimester of pregnancy did not seem to cause any untoward effects on the developing foetus, or any long\u2010lasting effects that could be detected during 6\u00a0years of follow\u2010up of the child.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.16120","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T22:56:08Z","timestamp":1718751368000},"page":"2554-2561","source":"Crossref","is-referenced-by-count":4,"title":["Pharmacokinetic study of erlotinib in a pregnant woman with advanced non\u2010small cell lung cancer and observation of the effects on the child growth"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6269-0586","authenticated-orcid":false,"given":"Yuka","family":"Aida","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine University of Tsukuba Hospital  Tsukuba Japan"},{"name":"Department of Medical Oncology University of Tsukuba Hospital  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Ohgami","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Ibaraki Prefectural Central Hospital  Kasama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5662-0418","authenticated-orcid":false,"given":"Yuji","family":"Mukai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Tsukuba Hospital  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine University of Tsukuba Hospital  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mana","family":"Obata\u2010Yasuoka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyomi","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Tsukuba Hospital  Tsukuba Japan"},{"name":"Department of Pharmaceutical Sciences, Graduate School of 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