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Although not the only source of the current epidemic of opioid use disorder (OUD), the prescription of opioids for chronic pain remains one vector for the development of opioid misuse and OUD. However, opioid tapering is not appropriate for all patients, and some patients may need to remain on opioid therapy for the long term. To reduce the risk of opioid\u2010related harm among people with chronic pain and to treat incipient or entrenched addictive behaviours, new interventions are needed. This review discusses the clinical outcomes, biobehavioural mechanisms and implementation considerations for a novel, evidence\u2010based intervention for chronic pain, opioid use and OUD called Mindfulness\u2010Oriented Recovery Enhancement (MORE). MORE unites complementary aspects of mindfulness training, cognitive behavioural therapy and principles from positive psychology to simultaneously address addictive behaviour, emotion dysregulation and chronic pain by targeting brain reward and stress systems. MORE has been tested in 13 completed randomized clinical trials, including over 1300 patients, and has demonstrated efficacy against a range of active control conditions for reducing opioid dosing, opioid misuse, illicit drug use, depression, post\u2010traumatic stress symptoms and chronic pain. Opportunities for implementing MORE include facilitating opioid tapering and promoting safe opioid use in primary care and specialty pain clinics, decreasing opioid misuse and enhancing medication\u2010assisted treatment for OUD. Given evidence of MORE's efficacy, it is now time to consider disseminating this evidence\u2010based treatment in the United States, the United Kingdom and worldwide.<\/jats:p>","DOI":"10.1111\/bcp.16147","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T11:58:55Z","timestamp":1721822335000},"page":"3028-3035","source":"Crossref","is-referenced-by-count":16,"title":["Mindfulness\u2010Oriented Recovery Enhancement: Implementing an evidence\u2010based intervention for chronic pain, opioid use, and opioid addiction in clinical settings"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2891-857X","authenticated-orcid":false,"given":"Eric L.","family":"Garland","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of California\u2010San Diego  La Jolla California USA"},{"name":"Sanford Institute for Empathy and Compassion University of California\u2010San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Empire of Pain: the Secret History of the Sackler Dynasty","author":"Keefe PR","year":"2021"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/M17\u20100865"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/20494637231160684"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14\u20102559"},{"key":"e_1_2_10_6_1","unstructured":"McCance\u2010Katz E. 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