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The search was carried out without date restrictions, up to the search date (April, 2023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the end of the selection process, 30 articles met the inclusion criteria. Cutaneous reactions were the primary serious clinical manifestations in most articles (19\/30), followed by erythema multiforme (71 cases), Stevens\u2013Johnson syndrome (72 cases), and toxic epidermal necrolysis (22 cases). The main antimicrobials involved in moderate and severe ADRs were penicillins, cephalosporins and sulfonamides. Regarding the primary outcomes, 30% (9\/30) of the articles reported deaths, and 46.7% (14\/30) of studies reported increased lengths of hospital stay, need for intensive care, and transfer to another hospital. Regarding the main interventions, 10% (3\/30) of the articles mentioned greater monitoring, suspension, medication substitution or prescription of specific medications for the symptomatology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings of this review could be used to identify areas for improvement and help health professionals and policymakers develop strategies. 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