{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:38:33Z","timestamp":1792193913808,"version":"4.4.0"},"reference-count":57,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006790","name":"College of Pharmacy, University of Michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006790","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Dried blood volumetric absorptive microsamples (VAMS) may facilitate home\u2010based sampling to enhance therapeutic drug monitoring after transplantation. This study aimed to clinically validate a liquid chromatography\u2013tandem mass spectrometry assay using 2 VAMS devices with different sampling locations (Tasso\u2010M20 for the upper arm and Mitra for the finger). Patient preferences were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical validation was performed for tacrolimus and mycophenolic acid by comparison of paired VAMS and venipuncture samples using Passing\u2013Bablok regression and Bland\u2013Altman analysis. Conversion of mycophenolic acid VAMS to serum concentrations was evaluated using haematocrit\u2010dependent formulas and fixed correction factors defined a priori. Patients' perspectives, including useability, acceptability and feasibility, were also investigated using established questionnaires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Paired samples (\n                      <jats:italic>n\u2009=<\/jats:italic>\n                      \u00a050) were collected from 25 kidney transplant recipients. Differences for tacrolimus whole\u2010blood concentration were within \u00b120% for 86 and 88% of samples from the upper arm and fingerstick, respectively. Using correction factors of 1.3 for the upper\u2010arm and 1.47 for finger\u2010prick samples, 84 and 76% of the paired samples, respectively, were within \u00b120% for mycophenolic acid serum concentration. Patient experience surveys demonstrated limited pain and acceptable useability of the upper\u2010arm device.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tacrolimus and mycophenolic acid can be measured using 2 common VAMS devices with similar analytical performance. Patients are supportive of home\u2010based monitoring with a preference for the Tasso\u2010M20 device.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcp.16182","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T05:15:49Z","timestamp":1721884549000},"page":"2897-2909","source":"Crossref","is-referenced-by-count":14,"title":["Clinical validation of two volumetric absorptive microsampling devices to support home\u2010based therapeutic drug monitoring of immunosuppression"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4310-4697","authenticated-orcid":false,"given":"Abbie D.","family":"Leino","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, College of Pharmacy University of Michigan  Ann Arbor MI 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