{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T15:29:12Z","timestamp":1773502152587,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Gastro\u2010oesophageal reflux is common in newborns, especially in premature infants. Treatment by medication is controversial as the drugs prescribed have not been consistently proven to be effective and are known to have adverse effects. This study sought to identify trends in the prescription of anti\u2010reflux medication in a large group of French neonatal units.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on prescriptions of anti\u2010reflux treatments\u2014proton pump inhibitors (PPIs), antacids, histamine\u20102 receptor antagonists (H2RAs), and prokinetics\u2014from 2014 to 2022 for infants with a corrected gestational age &lt;45\u2009weeks, were extracted from a prescription database (Logipren\u00ae) used by 63 French neonatal units, and then analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of all infants recorded in the database during the study period (<jats:italic>n\u2009=<\/jats:italic>\u00a0152\u2009743), 10.2% (<jats:italic>n<\/jats:italic>\u2009=\u200915\u2009650) were prescribed anti\u2010reflux medication (95% confidence interval [CI] 10.0\u201310.4%), mainly as monotherapy (77.5%). The rate was higher in the subgroup of preterm infants born before 28\u2009weeks of gestation (<jats:italic>n<\/jats:italic>\u2009=\u20099493) (20.6%, 95% CI 19.8\u201321.4%; <jats:italic>n<\/jats:italic>\u2009=\u20091956). PPIs were the most commonly prescribed anti\u2010reflux medications (6.9% of infants, 95% CI 6.8\u20137.0), followed by antacids (5.2%, 95% CI 5.1\u20135.3%), while H2RAs and prokinetics were rarely prescribed. Over the period, the prescription rate remained stable for PPIs, decreased for H2RAs (\u03c4\u2009=\u2009\u22120.86, <jats:italic>P<\/jats:italic>\u2009=\u2009.02), and, among preterm infants born at gestational ages of 28\u201331 or 32\u201336\u2009weeks, increased for antacids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anti\u2010reflux medications were frequently prescribed by neonatal units, especially for extremely premature infants. Most of these prescriptions were for PPIs and antacids.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.16198","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T03:54:50Z","timestamp":1723089290000},"page":"3201-3211","source":"Crossref","is-referenced-by-count":2,"title":["Prescriptions of anti\u2010reflux drugs in neonatology and neonatal intensive care units: A large multicentre observational study (2014\u20132022)"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0547-4566","authenticated-orcid":false,"given":"Manon","family":"Tauzin","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit Centre Hospitalier Intercommunal de Cr\u00e9teil (CHIC)  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9atrice","family":"Gouyon","sequence":"additional","affiliation":[{"name":"Centre d'\u00c9tudes P\u00e9rinatales de l'Oc\u00e9an Indien (CEPOI, EA7388) Universit\u00e9 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