{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:19:36Z","timestamp":1789471176741,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1F1A104996113"],"award-info":[{"award-number":["2021R1F1A104996113"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Chemotherapy\u2010induced peripheral neuropathy (CIPN) is a major toxicity limiting the use of nab\u2010paclitaxel (Nab\u2010P) in treating patients with pancreatic cancer. The aim of this study was to identify the factors affecting CIPN using patient\u2010reported outcome measures and the minimally invasive volumetric absorptive microsampling (VAMS) technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The maximum concentrations of paclitaxel (<jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>) were measured from 81 VAMS samples collected from 44 participants with pancreatic cancer. The association between CIPN development and demographic, clinical and pharmacokinetic factors was determined using univariable and multivariable logistic regression. The association between CIPN severity and the factors was evaluated using Spearman's rank correlation. The impact of <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub> and the number of treatment cycles on the severity was assessed using multivariable linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The development of CIPN was significantly associated with cumulative dose (odds ratio 1.005, 95% confidence interval [CI] 1.003\u20101.007), treatment cycles (3.47, 2.25\u20105.85), alkaline phosphate (0.992, 0.985\u20100.998) and age (1.092, 1.020\u20101.179), with an area under the receiver operating characteristic curve of 0.89 (95% CI 0.83\u20100.95). The severity of CIPN significantly worsened with increasing cumulative dose (coefficient 0.58, 95% CI 0.44\u20100.69), treatment cycles (0.57, 0.44\u20100.68) and age (0.18, 0.00\u20100.35). The severity of CIPN was predictable from treatment cycles (<jats:italic>P<\/jats:italic>\u2009=\u2009.0002) and <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub> (<jats:italic>P<\/jats:italic>\u2009=\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The higher the cumulative dose of Nab\u2010P, treatment cycles and age, the more frequently and severely do the patients experience CIPN. In predicting the severity of CIPN using <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>, minimally invasive VAMS is a feasible alternative to venous blood sampling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.16210","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T04:09:41Z","timestamp":1723867781000},"page":"3232-3241","source":"Crossref","is-referenced-by-count":7,"title":["Factors affecting peripheral neuropathy induced by nanoparticle albumin\u2010bound paclitaxel in patients with pancreatic cancer"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6818-5226","authenticated-orcid":false,"given":"Minseo","family":"Kang","sequence":"first","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghyun","family":"Yoo","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeolmae","family":"Jung","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayun","family":"Lim","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myeong Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8798-0491","authenticated-orcid":false,"given":"Ji Kon","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5565-8323","authenticated-orcid":false,"given":"Jangik I.","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.0017"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304369"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000524868"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24951"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.36695"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.04.021"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.937"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.10.017"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl18220"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2014.10.006"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001540"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864\u2010021\u201000926\u20100"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01399"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.02.012"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010017\u20101626\u20101"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx491"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010014\u20102255\u20107"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010013\u20100379\u20108"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.7074"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201005\u20100298"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201018\u20100656"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.07.029"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000001033"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.24304\/kjcp.2023.33.3.195"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.39.3.368"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.06.030"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.4097\/kja.21209"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.1514"},{"key":"e_1_2_11_30_1","volume-title":"Common terminology criteria for adverse events (CTCAE) version 5.0","author":"Department of Health and Human Services, National Institutes of Health, National Cancer Institute"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1327318"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0261473"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2018.01.001"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1586\/erp.10.15"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.29"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.2147\/PROM.S156279"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.3439"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(09)70200\u20101"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010019\u201004771\u20108"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S278892"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2016.12.012"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.66.2346"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018\u20100418"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010021\u201009069\u20109"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.5603\/GP.a2018.0034"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.16210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T07:56:35Z","timestamp":1732780595000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.16210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,16]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/bcp.16210"],"URL":"https:\/\/doi.org\/10.1111\/bcp.16210","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,16]]}}}