{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:24:39Z","timestamp":1782800679996,"version":"3.54.5"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100016714","name":"University of Sharjah","doi-asserted-by":"publisher","award":["22010901112"],"award-info":[{"award-number":["22010901112"]}],"id":[{"id":"10.13039\/100016714","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016714","name":"University of Sharjah","doi-asserted-by":"publisher","award":["22010901121"],"award-info":[{"award-number":["22010901121"]}],"id":[{"id":"10.13039\/100016714","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Age\u2010associated muscle loss, termed sarcopenia is the major cause of physical disability in patients with congestive heart failure (CHF). Angiotensin\u2010converting enzyme inhibitors (ACEi) are commonly used to treat CHF patients; however, their impacts on the neuromuscular junction (NMJ) and sarcopenia in CHF patients remain poorly understood. We aim to investigate the potential impact of ACEi on NMJ and CHF\u2010induced sarcopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cardiac function, short physical performance battery, handgrip strength (HGS), appendicular skeletal mass index, gait speed (GS) and plasma c\u2010terminal agrin fragment\u201022 (CAF22), a marker of NMJ degradation, were assessed in controls (<jats:italic>n\u2009=<\/jats:italic>\u00a081) and CHF patients treated with (<jats:italic>n\u2009=<\/jats:italic>\u00a0134) or without (<jats:italic>n\u2009=<\/jats:italic>\u00a0145) ACEi.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Irrespective of treatment, HGS and GS, indicators of sarcopenia, were profoundly declined in the patients with CHF <jats:italic>vs<\/jats:italic>. controls. However, patients on ACEi demonstrated significantly better HGS and GS compared to non\u2010ACEi patients (<jats:italic>P\u2009&lt;<\/jats:italic>\u2009.001). The level of CAF22 was significantly lower (<jats:italic>P\u2009&lt;<\/jats:italic>\u2009.0001) in the ACEi\u2010treated compared to non\u2010ACEi CHF patients. Further, the level of CAF22 was inversely correlated (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u2009.33, <jats:italic>P\u2009&lt;<\/jats:italic>\u2009.0001) with HGS in both ACEi and non\u2010ACEi CHF patients, while CAF22 was inversely correlated with GS and short physical performance battery only in ACEi\u2010treated but not in patients on other therapies without ACEi. The receiver operating characteristic curve analysis revealed CAF22 as a potential diagnostic marker (95% confidence interval: 0.785\u20130.883; <jats:italic>P\u2009&lt;<\/jats:italic>\u00a0.0001) for CHF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Collectively, these findings strongly suggest that ACEi limits CHF\u2010induced neuromuscular disjunction and physical disability in CHF. CAF22 has shown diagnostic implications for CHF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.16252","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T06:14:57Z","timestamp":1727504097000},"page":"409-419","source":"Crossref","is-referenced-by-count":5,"title":["Angiotensin\u2010converting enzyme inhibitors attenuate circulating CAF22 and physical decline in congestive heart failure: Diagnostic implications of CAF22"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6530-6068","authenticated-orcid":false,"given":"Firdos","family":"Ahmad","sequence":"first","affiliation":[{"name":"Basic Medical Sciences, College of Medicine University of Sharjah  Sharjah 27272 United Arab Emirates"},{"name":"Cardiovascular Research Group, Research Institute of Medical and Health Sciences University of Sharjah  Sharjah 27272 United Arab Emirates"},{"name":"Space Medicine Research Group, Research Institute of Medical and Health Sciences University of Sharjah  Sharjah 27272 United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asima","family":"Karim","sequence":"additional","affiliation":[{"name":"Basic Medical Sciences, College of Medicine University of Sharjah  Sharjah 27272 United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javaidullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Post Graduate Medical Institute Hayatabad Medical Complex  Peshawar 25120 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8485-7172","authenticated-orcid":false,"given":"Rizwan","family":"Qaisar","sequence":"additional","affiliation":[{"name":"Basic Medical Sciences, College of Medicine University of Sharjah  Sharjah 27272 United Arab Emirates"},{"name":"Cardiovascular Research Group, Research Institute of Medical and Health Sciences University of Sharjah  Sharjah 27272 United Arab Emirates"},{"name":"Space Medicine Research Group, Research Institute of Medical and Health Sciences University of Sharjah  Sharjah 27272 United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.11.007"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121150"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2022.08.009"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2016.03.018"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.068"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2019.03.020"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.165609"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.12.011"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520\u2010019\u201001290\u20108"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201087974\u20106"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2012.2514"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14588"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000065"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2004.52265.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(02)08024\u20108"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539\u2010011\u20100041\u20107"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046663"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13225"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.400"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.072090"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010230201"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/15353702231151980"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.09.009"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S225765"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/15353702231198080"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2022.08.004"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2023.107298"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010023\u201003547\u20102"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH12\u201010\u20100737"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/15353702221102117"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000001445"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495\u2010200161130\u201000001"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010020\u201001290\u20103"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102020\u2010321186"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075\u2010020\u20102141\u20102"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.04.014"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11090919"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aem144"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2013.01.010"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP089375"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.01.008"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00131"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2022.06.036"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031772"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344\u2010199203000\u201000005"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10061307"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e24655"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17875"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.9.1734"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944\u2010019\u20101145\u2010x"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.16252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T07:08:33Z","timestamp":1738048113000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.16252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,27]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/bcp.16252"],"URL":"https:\/\/doi.org\/10.1111\/bcp.16252","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,27]]}}}