{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:32:11Z","timestamp":1788262331499,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T00:00:00Z","timestamp":1731110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Patients undergoing haemodialysis (HD) are at greater risk of methicillin\u2010resistant <jats:styled-content style=\"fixed-case\"><jats:italic>Staphylococcus aureus<\/jats:italic><\/jats:styled-content> infections requiring intravenous vancomycin. Close vancomycin therapeutic drug monitoring is warranted in HD patients as renal clearance is the primary elimination pathway. Clinically, population pharmacokinetics (popPK) model\u2010informed dosing is commonly used. This study aimed to perform an external evaluation of published vancomycin popPK models developed for adults undergoing high\u2010flux intermittent HD, and to create a dosing nomogram derived from the model that performed best.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature review was conducted through PubMed and EMBASE to identify relevant popPK models. an external dataset was collected retrospectively from patients of 2 healthcare centres in Quebec, Canada. Selected models were implemented in <jats:italic>NONMEM<\/jats:italic> (v7.5; ICON Development Solutions). Predictive performance was assessed through prediction and simulation\u2010based diagnostics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 2386 vancomycin concentrations were collected from 274 patients and 476 antibiotic courses. Four vancomycin popPK models were selected for evaluation. None of the models demonstrated overall satisfactory or clinically acceptable predictive performance. Nonetheless, Bae et al.\u2019s model performed best with a median prediction error of 16.25% and median absolute prediction error of 34.66%. Different predictive performance was also observed for vancomycin concentrations from samples collected during and between HD sessions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>All evaluated models presented poor overall predictive performance. Further studies are required, through existing popPK model parameter re\u2010estimation or new model development, to adequately describe vancomycin pharmacokinetics for our high\u2010flux intermittent HD patient cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.16334","type":"journal-article","created":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T11:28:33Z","timestamp":1731151713000},"page":"856-865","source":"Crossref","is-referenced-by-count":2,"title":["External evaluation of intravenous vancomycin population pharmacokinetic models in adults receiving high\u2010flux intermittent haemodialysis"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1564-3340","authenticated-orcid":false,"given":"Cheng","family":"Ji","sequence":"first","affiliation":[{"name":"Pharmacy Department McGill University Health Center  Montr\u00e9al QC Canada"},{"name":"Faculty of Pharmacy Universit\u00e9 de Montr\u00e9al  Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Garcia","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Universit\u00e9 de Montr\u00e9al  Montr\u00e9al QC Canada"},{"name":"D\u00e9partement de pharmacie H\u00f4pital Charles\u2010Le Moyne  Greenfield Park QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argem Joy","family":"Sabuga","sequence":"additional","affiliation":[{"name":"Pharmacy Department McGill University Health Center  Montr\u00e9al QC Canada"},{"name":"Faculty of Pharmacy Universit\u00e9 de Montr\u00e9al  Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurane","family":"Ricard","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Universit\u00e9 de Montr\u00e9al  Montr\u00e9al QC Canada"},{"name":"D\u00e9partement de pharmacie H\u00f4pital Charles\u2010Le Moyne  Greenfield Park QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"France","family":"Dion","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Universit\u00e9 de Montr\u00e9al  Montr\u00e9al QC Canada"},{"name":"D\u00e9partement de pharmacie H\u00f4pital Charles\u2010Le Moyne  Greenfield Park QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad Alexandru","family":"Rosu","sequence":"additional","affiliation":[{"name":"Pharmacy Department McGill University Health Center  Montr\u00e9al QC Canada"},{"name":"Faculty of Pharmacy Universit\u00e9 de Montr\u00e9al  Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010\u00c8ve","family":"Legris","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Universit\u00e9 de Montr\u00e9al  Montr\u00e9al QC Canada"},{"name":"D\u00e9partement de pharmacie H\u00f4pital Charles\u2010Le Moyne  Greenfield Park QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9303-8862","authenticated-orcid":false,"given":"Am\u00e9lie","family":"Marsot","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Universit\u00e9 de Montr\u00e9al  Montr\u00e9al QC Canada"},{"name":"Laboratoire de Suivi Th\u00e9rapeutique Pharmacologique et Pharmacocin\u00e9tique, Facult\u00e9 de Pharmacie Universit\u00e9 de Montr\u00e9al  Montr\u00e9al QC Canada"},{"name":"Centre de recherche du CHU Ste\u2010Justine Centre hospitalier universitaire Ste\u2010Justine  Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3106-1052","authenticated-orcid":false,"given":"Van Dong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Pharmacy Department McGill University Health Center  Montr\u00e9al QC Canada"},{"name":"Faculty of Pharmacy Universit\u00e9 de Montr\u00e9al  Montr\u00e9al QC Canada"},{"name":"Laboratoire de Suivi Th\u00e9rapeutique Pharmacologique et Pharmacocin\u00e9tique, Facult\u00e9 de Pharmacie Universit\u00e9 de Montr\u00e9al  Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.14740\/wjnu384"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40697\u2010016\u20100115\u20108"},{"key":"e_1_2_10_4_1","unstructured":"Institut national de sant\u00e9 publique du Qu\u00e9bec (INSPQ).Surveillance provinciale des infections nosocomiales \u2013 Bact\u00e9ri\u00e9mies associ\u00e9es aux acc\u00e8s vasculaires en h\u00e9modialyse 2021\u20132022 [Internet]. 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