{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:55:32Z","timestamp":1773028532910,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The ideal dosing weight metric for enoxaparin remains elusive. Dosing remains focused on actual body weight, which may inadvertently increase the risk of bleeding in those with obesity, or ideal weight, which may underdose those with obesity. Our aim was to determine the optimal obesity\u2010adjusted enoxaparin dosing weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multisite retrospective data were collected over a 2.0\u2010year period for those with minimum 48\u2009h of in\u2010hospital twice\u2010daily enoxaparin and factor anti\u2010Xa level 3\u20135\u00a0h postdose (<jats:italic>n<\/jats:italic>\u00a0=\u2009220). Multiple linear regression calculated the associated variance between a range of nominal dosing weights and factor anti\u2010Xa levels, adjusted for renal function. Dosing weights were calculated as ideal body weight (IBW) and then adjusted for increasing percentages of weight above IBW, i.e. IBW\u2009+\u00a010% above IBW, IBW\u2009+\u200920% etc. up to actual body weight. A similar approach was used for lean body weight (LBW).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For body mass index\u2009\u226530\u2009kg\/m<jats:sup>2<\/jats:sup> optimal variance explained by dosing weight metrics was at IBW\u2009+\u200940% (23%) and similarly for LBW\u2009+\u200940% (23%). Using actual body weight (ABW) had lowest associated variance with factor anti\u2010Xa levels (18%) followed by unadjusted IBW (13%) or unadjusted LBW (19%). In those with body mass index\u2009&lt;30\u2009kg\/m<jats:sup>2<\/jats:sup> there was similar associated variance in the ranges of IBW\u2009+\u200920\u201350% and LBW 10\u201340% (21%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared to IBW\u2009+\u200940% or LBW\u2009+\u200940% use of ABW to calculate dose was poorly associated with factor anti\u2010Xa levels, as was IBW or LBW. IBW\u2009+\u200940% and LBW\u2009+\u200940% require further study as a dosing weight metric and may provide a more consistent factor anti\u2010Xa response in those with obesity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.16338","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T09:03:26Z","timestamp":1732179806000},"page":"1182-1190","source":"Crossref","is-referenced-by-count":2,"title":["Determination of the optimal obesity\u2010adjusted dosing weight for enoxaparin"],"prefix":"10.1111","volume":"91","author":[{"given":"Gregory W.","family":"Roberts","sequence":"first","affiliation":[{"name":"SA Pharmacy, Southern Adelaide Local Health Network  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6052-0273","authenticated-orcid":false,"given":"Viviane","family":"De Menezes Caceres","sequence":"additional","affiliation":[{"name":"Allied Health and Human Performance University of South Australia  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Damiani","sequence":"additional","affiliation":[{"name":"SA Pharmacy, Central Adelaide Local Health Network  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Scarfo","sequence":"additional","affiliation":[{"name":"SA Pharmacy, Southern Adelaide Local Health Network  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desmond B.","family":"Williams","sequence":"additional","affiliation":[{"name":"Pharmacy and Biomedical Sciences University of South Australia  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick T.","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Royal Adelaide Hospital, Central Adelaide Local Health 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