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A cerebrospinal fluid investigation in \u22651 episode was a prerequisite for inclusion. Sixty articles reporting on 74 patients experiencing a total of 155 episodes were retained. Forty\u2010five (61%) patients had one or more recurrences. Median age at first episode was 43 (interquartile range [IQR] 23\u201361) years. Symptoms presented within 48 (IQR 6\u2013168) hours of intake at the first episode and within 1.3 (IQR 1\u20135) hours at recurrences (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.0001). Cerebrospinal fluid analysis revealed a predominantly neutrophilic (82%, IQR 65%\u201394%) pleocytosis (180, IQR 38\u2013507\u200910<jats:sup>6<\/jats:sup>\u00a0cells\/L), without low glucose or high proteins. Recovery took place within 2 (IQR 1\u20133) days after stopping the suspected agent. All but one patient completely recovered.<\/jats:p>","DOI":"10.1111\/bcp.16346","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T11:16:58Z","timestamp":1731583018000},"page":"236-243","source":"Crossref","is-referenced-by-count":4,"title":["Acute aseptic meningitis temporally associated with trimethoprim and sulfamethoxazole: Systematic review"],"prefix":"10.1111","volume":"91","author":[{"given":"Gianmaria F.","family":"Bernasconi","sequence":"first","affiliation":[{"name":"Faculty of Biomedical Sciences Universit\u00e0 della Svizzera italiana  Lugano Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3829-4254","authenticated-orcid":false,"given":"Gregorio P.","family":"Milani","sequence":"additional","affiliation":[{"name":"Pediatric Unit Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Clinical Sciences and Community Health Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta L. 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