{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T15:16:58Z","timestamp":1793978218838,"version":"4.8.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The use of (GLP\u20101 RAs) among pregnant women is escalating, yet safety data remain insufficient. This study aims to comprehensively assess adverse drug reactions (ADRs) associated with GLP\u20101 RAs in pregnant women using the US Food and Drug Administration Adverse Event Reporting System (FAERS) database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>FAERS data from 2004 to 2023 were analysed, focusing on pregnant women aged 15\u201355\u2009years exposed to GLP\u20101 RAs. Descriptive analysis covered patient demographics, clinical aspects and annual trends. Disproportionality analysis used reporting odds ratio and Bayesian confidence propagation neural network to detect ADR signals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 354 cases with 1671 ADR reports, an exponential rise in reported cases since 2012 was observed. The median age of the affected women was 36\u2009years, with 50.56% classified as advanced age pregnant. The disproportionality analysis revealed significant ADR signals in the reproductive (\n                      <jats:italic>n\u2009=<\/jats:italic>\n                      \u00a0199) and gastrointestinal systems (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u2009155), with spontaneous abortion and pre\u2010eclampsia being the most concerning. Additionally, while no significant dose\u2010related differences were found, the age subgroup analysis indicated heightened risk across most age groups, except for those aged 20\u201324\u2009years, highlighting the need for careful monitoring of GLP\u20101 RAs used during pregnancy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights increasing GLP\u20101 RA use in pregnant women and identifies potential pregnant ADRs. GLP\u20101 RAs are not recommended for use during pregnancy. In cases of unintentional exposure, close monitoring is advised to ensure maternal and foetal safety. These findings provide valuable insights for clinicians making informed decisions and regulators considering using GLP\u20101 RA in pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcp.16354","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:36Z","timestamp":1733875236000},"page":"1272-1280","source":"Crossref","is-referenced-by-count":26,"title":["The safety profile of usage of glucagon\u2010like peptide\u20101 receptor agonists in pregnancy: A pharmacovigilance analysis based on the Food and Drug Administration Adverse Event Reporting System"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4405-0440","authenticated-orcid":false,"given":"Jianxing","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Pharmacy Fujian Medical University Union Hospital  Fuzhou Fujian 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