{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:27:21Z","timestamp":1781659641012,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The suitability of the DOAC score for assessing bleeding risk in Chinese patients with atrial fibrillation (AF) who are receiving non\u2010vitamin K antagonist oral anticoagulants (NOACs) remains unclear. We compared the DOAC score to the HAS\u2010BLED and ORBIT scores in Chinese patients in a real\u2010world retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The efficacy of these scores was assessed by a comparison study that measured their discrimination, calibration, net reclassification index (NRI), and decision curve analysis (DCA) over a 1\u2010year follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 2532 patients with non\u2010valvular AF (mean age, 71.7 \u00b1 11.3 years, 58.5% men), major bleeding (MB) occurred in 91 patients (3.59%\/year): 44 intracranial haemorrhage (ICH) events (1.74%\/year) and 49 gastrointestinal bleeding (GB) events (1.94%\/year). The best predictor for MB was the HAS\u2010BLED score (area under the receiver operating characteristic curve [AUC], 0.674). HAS\u2010BLED score \u22653 provided the best prediction for MB (AUC, 0.642), followed by DOAC score \u22658 and ORBIT score \u22654 (AUCs of 0.615 and 0.583, respectively). The DOAC and HAS\u2010BLED scores did not differ significantly in discriminating MB events and risk reclassification. The calibration performance of the HAS\u2010BLED score was superior to that of the other two scores. Decision curve analysis showed that using the HAS\u2010BLED score to predict MB and ICH is clinically beneficial. However, there were no significant distinctions among the three models in forecasting GB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a non\u2010valvular AF Chinese patients receiving NOACs, the HAS\u2010BLED score showed an ability to predict MB comparable to that of the DOAC score and superior to that of the ORBIT score. The DOAC score does not seem to be more suitable for Chinese patients than the HAS\u2010BLED score.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.16396","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T01:11:33Z","timestamp":1737594693000},"page":"1705-1715","source":"Crossref","is-referenced-by-count":6,"title":["Assessing the applicability of the DOAC, HAS\u2010BLED and ORBIT risk scores in Chinese patients on non\u2010vitamin K antagonist oral anticoagulants"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6675-1195","authenticated-orcid":false,"given":"Miao","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Pharmacy The First Affiliated Hospital of Ningbo University  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Yin","sequence":"additional","affiliation":[{"name":"School of International Business China Pharmaceutical University  Nanjing 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