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Computer\u2010controlled and hand\u2010held algometry were applied to the skin area covering right and left medial tibia before and after local anaesthesia (<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>) of the skin and reproducibility was evaluated. Pain experience (<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>c<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ill questionnaire) was compared between healthy volunteers and 12 patients with vertebral fractures.<jats:italic>Computer\u2010controlled algometer:<\/jats:italic>No differences in<jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>between study sessions for 6 and 8\u2010mm probes (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.43 and 0.32) were seen. There was a difference in<jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>before and after<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>for the 6\u2010mm probe (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.008), but not for the 8\u2010mm probe (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.26).<jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>and\u2010held algometer:<\/jats:italic>A difference in<jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>between study sessions was observed for 4\u2010 and 8\u2010mm probes (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.03 and 0.007), but not for 2, 6 and 10\u2010mm probes (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.19, 0.05 and 0.25). No differences in<jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>were seen before and after<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>for 2, 4, 8 and 10\u2010mm probes (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.35, 0.15, 0.08 and 0.53), but<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>significantly influenced<jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>with the 6\u2010mm probe (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.01). Similar words were chosen in the<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>c<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ill pain questionnaire by healthy volunteers and patients, qualitatively describing the deep pain sensation. The pain evoked by hand\u2010held algometer and the 2\u2010mm probe was not influenced by<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>, and<jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>was reproducible between sessions and is recommended for studies of experimentally evoked bone\u2010associated pain.<\/jats:p>","DOI":"10.1111\/bcpt.12002","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T12:35:30Z","timestamp":1365424530000},"page":"116-123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A Human Experimental Bone Pain Model"],"prefix":"10.1111","volume":"112","author":[{"given":"Trine","family":"Andresen","sequence":"first","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology &amp; Hepatology Aalborg Hospital Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mogens","family":"Pfeiffer\u2010Jensen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Brock","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology &amp; Hepatology Aalborg Hospital Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asbj\u00f8rn M.","family":"Drewes","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology &amp; Hepatology Aalborg Hospital Aarhus University Aarhus Denmark"},{"name":"Center for Sensory\u2010Motor Interaction (SMI) Department of Health Science and Technology Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Arendt\u2010Nielsen","sequence":"additional","affiliation":[{"name":"Center for Sensory\u2010Motor Interaction (SMI) Department of Health Science and Technology Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,20]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1093\/bja\/aen100"},{"volume-title":"Textbook of Pain","year":"2006","author":"Wall P","key":"e_1_2_9_3_1"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1093\/ptj\/86.1.77"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.1016\/j.jpainsymman.2005.01.008"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1016\/S0140-6736(99)01310-0"},{"key":"e_1_2_9_7_1","first-page":"2364","article-title":"Malignant bone pain","volume":"159","author":"Thomsen CB","year":"1997","journal-title":"Ugeskr Laeger"},{"doi-asserted-by":"publisher","key":"e_1_2_9_8_1","DOI":"10.1007\/s00774-004-0507-1"},{"doi-asserted-by":"publisher","key":"e_1_2_9_9_1","DOI":"10.1002\/ar.1092090306"},{"doi-asserted-by":"publisher","key":"e_1_2_9_10_1","DOI":"10.1177\/104990919200900610"},{"doi-asserted-by":"publisher","key":"e_1_2_9_11_1","DOI":"10.1016\/j.pain.2006.01.032"},{"doi-asserted-by":"publisher","key":"e_1_2_9_12_1","DOI":"10.1124\/jpet.103.048835"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2340\/165019771993117124","article-title":"A comparison of pressure pain thresholds in different tissues and body regions. 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