{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T21:40:29Z","timestamp":1726436429388},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although exogenous and endogenous cannabinoid receptor agonists have well\u2010documented inhibitory effects on gastrointestinal motility, a <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>1 receptor\u2010mediated excitatory action of anandamide (arachidonoyl ethanolamide, <jats:styled-content style=\"fixed-case\">AEA<\/jats:styled-content>) in the guinea\u2010pig ileum strip has also been described. We used <jats:italic>in vitro<\/jats:italic> capsaicin desensitization for assessing the possible participation of sensory neurons in the contractile effect of anandamide on the guinea\u2010pig whole ileum, as well as autonomic drugs and a cyclooxygenase inhibitor for characterizing this response. Isolated organ experiments were used with isotonic recording. Contractions induced by anandamide (1 or 10\u00a0\u03bcM) were strongly inhibited by tetrodotoxin, indomethacin or atropine <jats:italic>plus<\/jats:italic> a tachykinin NK<jats:sub>1<\/jats:sub> receptor antagonist, but weakly to moderately reduced by atropine alone and partly diminished by the fatty acid amide hydrolase inhibitor URB 597. Neither capsaicin pre\u2010treatment nor the TRPV1 receptor antagonist BCTC, the ganglionic blocking drug hexamethonium or cannabinoid (CB<jats:sub>1<\/jats:sub> or CB<jats:sub>2<\/jats:sub>) receptor antagonists, influenced the effect of anandamide. It is concluded that the capsaicin\u2010insensitive, neuronal excitatory effect of anandamide in the intestine is most probably mediated by cyclooxygenase products. Such a mechanism may also play a role at other sites in the mammalian body.<\/jats:p>","DOI":"10.1111\/bcpt.12041","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T12:07:16Z","timestamp":1366114036000},"page":"341-345","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Contractile Effect of Anandamide in the Guinea\u2010Pig Small Intestine is Mediated by Prostanoids but not <scp>TRPV<\/scp>1 Receptors or Capsaicin\u2010Sensitive Nerves"],"prefix":"10.1111","volume":"112","author":[{"given":"Andr\u00e1s","family":"D\u00e9k\u00e1ny","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy University Medical School of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Benko","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy University Medical School of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Szombati","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy University Medical School of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorand","family":"Bartho","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy University Medical School of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(93)90154-P"},{"issue":"1","key":"e_1_2_7_3_1","article-title":"Guide to receptors and channels","volume":"164","author":"Alexander SPH","year":"2011","journal-title":"Br J Pharmacol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)90197-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)30024-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.38.1.179"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/22761"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01630-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704340"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.08.017"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2008.08.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.6.859"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701964"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.07.036"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00717.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704220"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01650-3"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)61097-3"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.07.020"},{"issue":"1","key":"e_1_2_7_20_1","first-page":"21","article-title":"Role of extrinsic afferent neurons in gastrointestinal motility","volume":"12","author":"Bartho L","year":"2008","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1998.275.1.G1"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2006.02.014"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.10.021"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2005.01.023"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1968.tb08492.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1983.tb10031.x"}],"container-title":["Basic &amp; 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