{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:44:17Z","timestamp":1791398657782,"version":"4.3.3"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T00:00:00Z","timestamp":1386720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tocolytic use of magnesium sulphate is associated with excess neonatal mortality and has been proposed to follow a dose\u2013response relationship. This study aimed to define the correlation between maternal and neonatal magnesium blood concentrations. Magnesium blood concentrations were retrospectively obtained for mother\u2013neonate pairs who were cared for at an Intermountain Healthcare facility from January 2009 to October 2011. Complete data were available for 231 mother\u2013neonate pairs. Mean (\u00b1SD) maternal and neonatal magnesium concentrations were 5.43\u00a0\u00b1\u00a01.69 and 2.98\u00a0\u00b1\u00a00.94\u00a0mg\/dL, respectively. Maternal and neonatal magnesium concentrations were highly correlated (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). In univariate analyses, residual unexplained variability was high (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.19). However, further multivariate analyses revealed that caesarian section, severe pre\u2010eclampsia and Apgar score at 5\u00a0min. were significantly associated with neonatal magnesium concentrations (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05 for all). Maternal magnesium concentrations correlate with neonatal exposure. This finding suggests that maternal monitoring deserves further evaluation as a marker of foetal toxicity.<\/jats:p>","DOI":"10.1111\/bcpt.12166","type":"journal-article","created":{"date-parts":[[2013,10,27]],"date-time":"2013-10-27T11:50:04Z","timestamp":1382874604000},"page":"318-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Maternal Magnesium Sulphate Exposure Predicts Neonatal Magnesium Blood Concentrations"],"prefix":"10.1111","volume":"114","author":[{"given":"Catherine M.T.","family":"Sherwin","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacology Department of Pediatrics University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Balch","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology Department of Pediatrics University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology Department of Pediatrics University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeunesse","family":"Fredrickson","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin A.S.","family":"Clark","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Varner","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology University of Utah School of Medicine Salt Lake City Utah USA"},{"name":"Intermountain Healthcare Women and Newborns Clinical Program Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Stockmann","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology Department of Pediatrics University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Kent","family":"Korgenski","sequence":"additional","affiliation":[{"name":"Intermountain Healthcare Pediatric Clinical Program Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua L.","family":"Bonkowsky","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology Department of Pediatrics University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Spigarelli","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology Department of Pediatrics University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/941057"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)24047-X"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001060"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00277-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00994.2004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801187"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.01.014"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880130808"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.53.030191.001503"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/33.11.1965"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6867714"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198405103101904"},{"key":"e_1_2_9_14_1","first-page":"449","article-title":"The effects of maternal magnesium sulfate treatment on newborns: a prospective controlled study","volume":"18","author":"Riaz M","year":"1998","journal-title":"J Perinatol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1542\/peds.95.2.263","article-title":"Can magnesium sulfate reduce the risk of cerebral palsy in very low birthweight infants?","volume":"95","author":"Nelson KB","year":"1995","journal-title":"Pediatrics"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.123544"},{"key":"e_1_2_9_17_1","unstructured":"U.S. Food and Drug Administration.FDA recommends against prolonged use of magnesium sulfate to stop pre\u2010term labor due to bone changes in exposed babies. 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