{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:04:27Z","timestamp":1762506267297},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T00:00:00Z","timestamp":1394755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>In vitro<\/jats:italic> studies have shown that selective serotonin reuptake inhibitors inhibit platelet aggregation. It is well documented that <jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content>s cause serious gastrointestinal bleeding, but studies on other bleeding manifestations have been equivocal. Our objective was to determine a possible association between use of serotonergic antidepressants (<jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>) and perioperative bleeding during hip replacements. We conducted a retrospective study between 1 January 2007 and 30 June 2012 among patients that underwent a primary unilateral uncemented total hip arthroplasty (<jats:styled-content style=\"fixed-case\">THA<\/jats:styled-content>). Information was collected on the observed blood loss and the need for blood transfusions among this group. We compared the blood loss between users of <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>, users of non\u2010serotonergic antidepressants (<jats:styled-content style=\"fixed-case\">NSA<\/jats:styled-content>) and non\u2010users, while adjusting for potential confounders using multivariate linear regression. We indentified 1318 patients that underwent a <jats:styled-content style=\"fixed-case\">THA<\/jats:styled-content> in the study period. The average volume of surgical bleeding was 350\u00a0ml. The adjusted incremental blood loss associated with use of <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NSA<\/jats:styled-content> was 93, 95% confidence interval (38\u2013147) ml and \u221250 (\u2212125 to 25) ml compared with non\u2010use. Only 48 subjects (3.6%) had transfusions. Use of <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> was associated with an increased blood loss compared with non\u2010users. The hypothesis that <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> impairs haemostasis is supported by these results.<\/jats:p>","DOI":"10.1111\/bcpt.12218","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T01:17:15Z","timestamp":1392772635000},"page":"277-281","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Association between Use of Serotonergic Antidepressants and Perioperative Bleeding during Total Hip Arthroplasty \u2013 A Cohort Study"],"prefix":"10.1111","volume":"115","author":[{"given":"Michael","family":"Dall","sequence":"first","affiliation":[{"name":"Research Unit of Clinical Pharmacology University of Southern Denmark Odense Denmark"},{"name":"Department of Medicine Odense University Hospital Svendborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Primdahl","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Kolding Hospital Kolding Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Damborg","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Kolding Hospital Kolding Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tine","family":"Nymark","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Hallas","sequence":"additional","affiliation":[{"name":"Research Unit of Clinical Pharmacology University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1468"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.81"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.21.2367"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.08.019"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199711000-00006"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(96)71592-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S146114570000198X"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.19.2354"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00129784-200606040-00004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181cf8fdf"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2482-10-3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-011-2132-8"},{"key":"e_1_2_8_14_1","volume-title":"ATC Index with DDDs and Guidelines for ATC Classification and DDD Assignment","author":"WHO Collaborating Centre for Drug Statistics Methodology","year":"2006"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000018589.56991.BA"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5462.2398"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01393-9"},{"key":"e_1_2_8_18_1","first-page":"445","article-title":"The Danish Prescription Registries","volume":"44","author":"Gaist D","year":"1997","journal-title":"Dan Med Bull"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1999.01181.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07369-5"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2004.09.061"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200407000-00001"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199901000-00002"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.94B11.30618"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.04004.x"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcpt.12218","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.12218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:49:56Z","timestamp":1695484196000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.12218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,14]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/bcpt.12218"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.12218","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,14]]},"assertion":[{"value":"2013-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}