{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T04:08:47Z","timestamp":1780805327112,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T00:00:00Z","timestamp":1397174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","award":["n.a."],"award-info":[{"award-number":["n.a."]}],"id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Magnus Bergwall Foundation","award":["n.a."],"award-info":[{"award-number":["n.a."]}]},{"name":"Stockholm County Council and Karolinska Institutet (ALF)","award":["20110385"],"award-info":[{"award-number":["20110385"]}]},{"name":"Swedih Research Council","award":["No. 3902"],"award-info":[{"award-number":["No. 3902"]}]},{"name":"Swedish Foundation for Clinical Pharmacology and Pharmacotherapy","award":["n.a."],"award-info":[{"award-number":["n.a."]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>In vitro<\/jats:italic> studies have shown that vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> may induce several cytochrome <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>450 (<jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>) enzymes in general and <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>4 in particular. The primary aim of this study was to investigate the relationship between plasma levels of 25\u2010hydroxyvitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content><jats:sub>3<\/jats:sub> and suggested <jats:italic>in vivo<\/jats:italic> markers of <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> activity in healthy volunteers from <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>weden and <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>orea. Plasma concentrations of 25\u2010hydroxyvitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content><jats:sub>3<\/jats:sub> were analysed in samples from three previously performed studies, and the correlation between these levels and suggested <jats:italic>in vivo<\/jats:italic> markers of <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> activity was investigated by means of nonparametric correlation. In addition, we studied the modulating effects of three vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> receptor promoter polymorphisms on the association between 25\u2010hydroxyvitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content><jats:sub>3<\/jats:sub> and <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> enzyme activity in Swedish subjects. The plasma levels of 25\u2010hydroxyvitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content><jats:sub>3<\/jats:sub> were not significantly associated with <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> phenotypes in any of the three studies, but after accounting for the vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> receptor polymorphism rs4516035, there was a significant positive association between 25\u2010hydroxyvitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content><jats:sub>3<\/jats:sub> and <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> activity (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.004). Swedes (n\u00a0=\u00a065) had significantly higher 25\u2010hydroxyvitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content><jats:sub>3<\/jats:sub> levels than <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>oreans (n\u00a0=\u00a067), 75\u00a0nM compared with 31\u00a0nM (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001). Swedish women taking oral contraceptives (<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>) (n\u00a0=\u00a019) had somewhat higher plasma levels of 25\u2010hydroxyvitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content><jats:sub>3<\/jats:sub> compared with <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>wedish women not taking oral contraceptives (n\u00a0=\u00a021), 89 and 72\u00a0nM, respectively (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.02). In conclusion, our results suggest that the overall influence on the <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> activity by 25\u2010hydroxyvitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content><jats:sub>3<\/jats:sub> is of marginal importance.<\/jats:p>","DOI":"10.1111\/bcpt.12230","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T08:22:46Z","timestamp":1395390166000},"page":"366-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Plasma Levels of 25\u2010Hydroxyvitamin <scp>D<\/scp><sub>3<\/sub> and <i>In Vivo<\/i> Markers of Cytochrome <scp>P<\/scp>450 3<scp>A<\/scp> Activity in Swedes and Koreans: Effects of a Genetic Polymorphism and Oral Contraceptives"],"prefix":"10.1111","volume":"115","author":[{"given":"Hanna","family":"Nyl\u00e9n","sequence":"first","affiliation":[{"name":"Division of Clinical Chemistry Department of Laboratory Medicine Karolinska Institutet Karolinska University Hospital Huddinge Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Bj\u00f6rkhem\u2010Bergman","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology Department of Laboratory Medicine Karolinska Institutet Karolinska University Hospital Huddinge Stockholm Sweden"},{"name":"Division of Clinical Pharmacology Department of Laboratory Medicine Karolinska Institutet Karolinska University Hospital Huddinge Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology Department of Laboratory Medicine Karolinska Institutet Karolinska 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