{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:09:37Z","timestamp":1787224177526,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Startup Project of Doctor scientific research by Sichuan University of Science and Engineering.","award":["2013RC14"],"award-info":[{"award-number":["2013RC14"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Puerarin (<jats:styled-content style=\"fixed-case\">PU<\/jats:styled-content>), a natural flavonoid, has been reported to have many benefits and medicinal properties. The aim of this study was to investigate the effects of puerarin on hepatic oxidative stress and hyperlipidaemia in mice exposed to carbon tetrachloride (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>). Male <jats:styled-content style=\"fixed-case\">ICR<\/jats:styled-content> mice were injected with <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub> with or without puerarin co\u2010administration (200 and 400\u00a0mg\/kg intragastrically once\u2010daily) for 8\u00a0weeks. Our data showed that puerarin significantly prevented <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>\u2010induced hepatotoxicity, indicated by both diagnostic indicators of the liver damage (serum aminotransferase levels) and histopathological analysis. Puerarin decreased the thiobarbituric acid reactive substances (<jats:styled-content style=\"fixed-case\">TBARS<\/jats:styled-content>) and the protein carbonyl content (<jats:styled-content style=\"fixed-case\">PCO<\/jats:styled-content>) in the liver of <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>\u2010treated mice. Puerarin also restored the levels of reduced glutathione (<jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content>) and total antioxidant capacity (<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>) in the liver. Furthermore, the increase in serum cholesterol, triglycerides and low\u2010density lipoproteins (<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>) induced by <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub> was effectively suppressed by puerarin. The high\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>) level in the <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub> treatment mice was also increased by puerarin. Western blot analysis showed that puerarin remarkably inhibited hyperlipidaemia by regulating the expression of phosphorylated Jun N\u2010terminal kinases (<jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>), phosphorylated c\u2010Jun protein and cholesterol 7a\u2010hydroxylase (<jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>7A1) in the liver of <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>\u2010treated mice. Altogether, these results suggest that puerarin could protect the <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>\u2010induced liver injury and hyperlipidaemia by reducing reactive oxygen species S production, renewing the total antioxidant capacity and influencing expression of hepatic lipid biosynthesis and metabolism genes.<\/jats:p>","DOI":"10.1111\/bcpt.12245","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T13:59:59Z","timestamp":1396533599000},"page":"389-395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Puerarin Attenuates Carbon Tetrachloride\u2010Induced Liver Oxidative Stress and Hyperlipidaemia in Mouse by <scp>JNK<\/scp>\/c\u2010Jun\/CYP7A1 Pathway"],"prefix":"10.1111","volume":"115","author":[{"given":"Jie\u2010Qiong","family":"Ma","sequence":"first","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Sichuan University of Science and Engineering Zigong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Sichuan University of Science and Engineering Zigong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Sichuan University of Science and Engineering Zigong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan\u2010Min","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Science Jiangsu Normal University Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2011.11.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.06.015"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2011.600765"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.11.017"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/jbcpp-2012-0053"},{"key":"e_1_2_7_7_1","first-page":"500","article-title":"Bile acid metabolism in the cirrhotic rat","volume":"41","author":"Hanson RF","year":"1979","journal-title":"Lab Invest"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25905"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.06.035"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02980272"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.09.007"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2012.00864.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.02.051"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.10.059"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.09.036"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.09.077"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf304562b"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2011.01.017"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2011.11.015"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(94)33041-7"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2009.05.020"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1575"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-008-9791-0"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.11.005"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2008.00214.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.01.016"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010878200"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.09234FP"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2010.00615.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.10.002"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.05.061"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2013.06.008"}],"container-title":["Basic &amp; 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