{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:04:17Z","timestamp":1790899457758,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T00:00:00Z","timestamp":1400457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Board of Health and Welfare in Sweden"},{"name":"Swedish Academy of Pharmaceutical Sciences (SAPS)"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Therapeutic modulation of pain with morphine and other opioids is associated with significant variation in both effects and adverse effects in individual patients. Many factors including gene polymorphisms have been shown to contribute to the interindividual variability in the response to opioids. The aim of this study was to investigate the significance of <jats:styled-content style=\"fixed-case\"><jats:italic>UGT<\/jats:italic><\/jats:styled-content><jats:italic>2<\/jats:italic><jats:styled-content style=\"fixed-case\"><jats:italic>B<\/jats:italic><\/jats:styled-content><jats:italic>7<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> <jats:italic>OPRM<\/jats:italic><\/jats:styled-content><jats:italic>1<\/jats:italic> and <jats:styled-content style=\"fixed-case\"><jats:italic>ABCB<\/jats:italic><\/jats:styled-content><jats:italic>1<\/jats:italic> polymorphisms for interindividual variability in morphine\u2010induced analgesia in patients undergoing hysterectomy. The frequency of these polymorphisms was also investigated in forensic autopsies as morphine is also a very commonly abused drug. Blood samples were collected from 40 patients following abdominal hysterectomy, 24\u00a0hr after initiation of analgesia through a patient\u2010controlled analgesia (<jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>) pump. Samples were genotyped and analysed for morphine and its metabolites. We also genotyped approximately 200 autopsies found positive for morphine in routine forensic analysis. Patients homozygous for <jats:styled-content style=\"fixed-case\"><jats:italic>UGT<\/jats:italic><\/jats:styled-content><jats:italic>2<\/jats:italic><jats:styled-content style=\"fixed-case\"><jats:italic>B<\/jats:italic><\/jats:styled-content><jats:italic>7<\/jats:italic> 802<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> needed significantly lower dose of morphine for pain relief. The same trend was observed for patients homozygous for <jats:styled-content style=\"fixed-case\"><jats:italic>ABCB<\/jats:italic><\/jats:styled-content><jats:italic>1<\/jats:italic> 1236<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> and 3435<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>, as well as to <jats:styled-content style=\"fixed-case\"><jats:italic>OPRM<\/jats:italic><\/jats:styled-content><jats:italic>1<\/jats:italic> 118<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>. The dose of morphine in patients included in this study was significantly related to variation in <jats:styled-content style=\"fixed-case\"><jats:italic>UGT<\/jats:italic><\/jats:styled-content><jats:italic>2<\/jats:italic><jats:styled-content style=\"fixed-case\"><jats:italic>B<\/jats:italic><\/jats:styled-content><jats:italic>7 <\/jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>802<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>. Age was significantly related to both dose and concentration of morphine in blood. Regression analysis showed that 30% of differences in variation in morphine dose could be explained by <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in these genes. The genotype distribution was similar between the forensic cases and the patients. However, the mean concentration of morphine was higher in forensic cases compared to patients. We conclude that gene polymorphisms contribute significantly to the variation in morphine concentrations observed in individual patients.<\/jats:p>","DOI":"10.1111\/bcpt.12248","type":"journal-article","created":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T13:31:22Z","timestamp":1396618282000},"page":"423-431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Influence of <i><scp>UGT<\/scp>2B7<\/i>,<i><scp>OPRM<\/scp>1<\/i> and <i><scp>ABCB<\/scp>1 G<\/i>ene Polymorphisms on Postoperative Morphine Consumption"],"prefix":"10.1111","volume":"115","author":[{"given":"Salumeh","family":"Bastami","sequence":"first","affiliation":[{"name":"Unit for Development and Patient Safety Department of Medical and Health Sciences Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Lena","family":"Zackrisson","sequence":"additional","affiliation":[{"name":"Department of Forensic Genetics and Forensic Toxicology National Board of Forensic Medicine Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Ahlner","sequence":"additional","affiliation":[{"name":"Unit for Development and Patient Safety Department of Medical and Health Sciences Link\u00f6ping University Link\u00f6ping Sweden"},{"name":"Department of Forensic Genetics and Forensic Toxicology National Board of Forensic Medicine Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdimajid","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Department of Clinical and Experimental Medicine Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas","family":"Uppugunduri","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Department of Clinical and Experimental Medicine Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1191\/0269216304pm856oa"},{"key":"e_1_2_7_3_1","first-page":"259","article-title":"The minimum effective concentration of opioids: a revisitation with patient controlled analgesia fentanyl","volume":"25","author":"Woodhouse A","year":"2000","journal-title":"Reg Anesth Pain Med"},{"key":"e_1_2_7_4_1","first-page":"1","article-title":"Human UGT2B7 catalyzes morphine glucuronidation","volume":"25","author":"Coffman BL","year":"1997","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-011-9274-6"},{"key":"e_1_2_7_6_1","first-page":"73","article-title":"The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268)","volume":"26","author":"Coffman BL","year":"1998","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200011000-00002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.DMPK-12-RG-106"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-009-1029-2"},{"key":"e_1_2_7_10_1","first-page":"2655","article-title":"[Genetic variation\u2013 important for the clinical effect of opioids?]","volume":"125","author":"Klepstad P","year":"2005","journal-title":"Tidsskr Nor Laegeforen"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500362"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318182af21"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.16.9608"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.5.677"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2006.01058.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200308000-00006"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2010.09.011"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1520\/JFS14071J"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)80494-6"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.9.2542"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.10.023"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100385"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32835ce485"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e3181671a08"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3708"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.02923.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2004.00517.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.07.013"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000220566.90466.a2"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcpt.12248","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.12248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T10:41:59Z","timestamp":1696329719000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.12248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,19]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/bcpt.12248"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.12248","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,19]]},"assertion":[{"value":"2014-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}