{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:13:26Z","timestamp":1773162806899,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T00:00:00Z","timestamp":1402358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inflammatory activation plays a vital role in the pathophysiological mechanisms of stroke and diabetes mellitus (<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>), exerts the deleterious effects on the progression of the brain and leads to vascular damage in diabetic stroke. The objectives of this study were to investigate the effects of 8\u2010<jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>\u2010acetyl shanzhiside methylester (<jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content>01) on tumour necrosis factor\u2010\u03b1 (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1)\u2010stimulated <jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SY<\/jats:styled-content>5Y cell line <jats:italic>in vitro<\/jats:italic> and the experimental ischaemic diabetic stroke model <jats:italic>in vivo<\/jats:italic>. <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1\u2010stimulated <jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SY<\/jats:styled-content>5Y cells were pre\u2010incubated with <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content>01, then analysed protein expression. For <jats:italic>in vivo<\/jats:italic> experiment, the diabetic rats were subjected to middle cerebral artery occlusion (<jats:styled-content style=\"fixed-case\">MCAO<\/jats:styled-content>) for 30\u00a0min. followed by reperfusion for 23\u00a0hr. Treatment of <jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SY<\/jats:styled-content>5<jats:styled-content style=\"fixed-case\">Y<\/jats:styled-content> cells with <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content>01 blocked <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1\u2010induced nuclear transcription factor \u03baB (<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB) activation and decreased high\u2010mobility group box\u20101 (<jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>\u20101) expression. <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content>01 40\u00a0mg\/kg demonstrated significant neuroprotective effect even after delayed administration at 4\u00a0hr after I\/R. <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content>01 40\u00a0mg\/kg attenuated the histopathological damage, decreased brain swelling, inhibited <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB activation and reduced <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>\u20101 expression in ischaemic brain tissue. These data show that <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content>01 protects diabetic brain against <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content> injury with a favourable therapeutic time\u2010window by alleviating diabetic cerebral <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content> injury and attenuating blood\u2013brain barrier (<jats:styled-content style=\"fixed-case\">BBB<\/jats:styled-content>) breakdown, and its protective effects may involve <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB signalling pathway.<\/jats:p>","DOI":"10.1111\/bcpt.12266","type":"journal-article","created":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T18:58:51Z","timestamp":1400007531000},"page":"481-487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["8\u2010O\u2010Acetyl Shanzhiside Methylester Attenuates Cerebral Ischaemia\/Reperfusion Injury through an Anti\u2010Inflammatory Mechanism in Diabetic Rats"],"prefix":"10.1111","volume":"115","author":[{"given":"Liang","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Binzhou Medical University Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze\u2010Chun","family":"Kan","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Binzhou Medical University Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu\u2010Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Binzhou Medical University Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Fang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Binzhou Medical University Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang\u2010Lin","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Binzhou Medical University Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.618850"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70005-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821cccc2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60963-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-3787(05)85190-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.12.2792"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3815-05.2006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2435-08.2008"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600582"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.11.065"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2010.00620.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706718"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2978"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1990.47"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.9.1304"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.07.016"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490290309"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-7-55"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2007.04.015"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199607000-00003"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.12.028"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.541128"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/609202"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2925"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600324"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0902"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-11-04180.1997"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220182"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.202"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.06.004"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-10-28"},{"key":"e_1_2_6_33_1","first-page":"25","article-title":"Role of NF\u2010\u03baB in the central nervous system","volume":"59","author":"Ma\u0142ek R","year":"2007","journal-title":"Pharmacol Rep"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2011.00827.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(11)70505-9"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcpt.12266","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.12266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:37:52Z","timestamp":1696304272000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.12266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,10]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/bcpt.12266"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.12266","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,10]]},"assertion":[{"value":"2014-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}