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In this study, we characterized changes in hepatic copper concentrations and hepatic oxidative milieu, in rats with the metabolic syndrome and<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>as a result of<jats:styled-content style=\"fixed-case\">FED<\/jats:styled-content>with pharmacological manipulations to reduce blood pressure or plasma triglycerides. Changes in plasma and hepatic copper concentrations were correlated with changes observed in the immunohistochemical hepatic expression of copper\u2013zinc\u2013superoxide dismutase (CuZn<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>;<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>1), metallothionein (<jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>) and nitrotyrosine (<jats:styled-content style=\"fixed-case\">NITT<\/jats:styled-content>).<jats:styled-content style=\"fixed-case\">FED<\/jats:styled-content>administration was associated with a 2.2\u2010fold reduction in hepatic copper concentrations, a decrease in the hepatic<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>1 expression, disappearance of the hepatic<jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>expression and increase in the hepatic<jats:styled-content style=\"fixed-case\">NITT<\/jats:styled-content>expression. Bezafibrate administration restored the hepatic copper concentrations and the hepatic<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>1 expression to levels that were observed in the control rats. A significant positive correlation between hepatic copper concentrations and the values of hepatic<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>1 expression of each animal included in this study was found. Administration of either captopril or bezafibrate increased hepatic<jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>expression, however, to levels that were lower than those observed in the control group. Administration of either amlodipine, or captopril or bezafibrate to the<jats:styled-content style=\"fixed-case\">FED<\/jats:styled-content>rats, had no effect on hepatic<jats:styled-content style=\"fixed-case\">NITT<\/jats:styled-content>expression.<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>development in<jats:styled-content style=\"fixed-case\">FED<\/jats:styled-content>rats is associated with a decrease in hepatic copper concentrations that is associated with a decrease in the hepatic<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>1 expression. Bezafibrate administration increases hepatic copper concentrations and restores the hepatic<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>1 expression.<\/jats:p>","DOI":"10.1111\/bcpt.12283","type":"journal-article","created":{"date-parts":[[2014,6,28]],"date-time":"2014-06-28T15:46:31Z","timestamp":1403970391000},"page":"545-551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Antihypertensive and Triglyceride\u2010lowering Agents on Hepatic Copper Concentrations in Rats with Fatty Liver Disease"],"prefix":"10.1111","volume":"115","author":[{"given":"Zvi","family":"Ackerman","sequence":"first","affiliation":[{"name":"Departments of Medicine Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galina","family":"Skarzinski","sequence":"additional","affiliation":[{"name":"Departments of Medicine 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