{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:14:22Z","timestamp":1770740062404,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,13]],"date-time":"2014-09-13T00:00:00Z","timestamp":1410566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the effect of gamma\u2010aminobutyric acid (<jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>) on acute renal injury (<jats:styled-content style=\"fixed-case\">ARI<\/jats:styled-content>), we used here a rat model of acute tubular necrosis induced by the anticancer drug cisplatin (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> was given orally (100 or 500\u00a0mg\/kg\/day for ten consecutive days), and on the 6th day, some of the treated rats were also injected intraperitoneally with either saline or <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> (6\u00a0mg\/kg). Four days after <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> treatment, urine was collected from all rats, which were then anaesthetized for blood pressure and renal blood flow monitoring. This was followed by intravenous injection of norepinephrine for the assessment of renal vasoconstrictor responses. Thereafter, blood and kidneys were collected for measurement of several functional, biochemical and structural parameters. <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> treatment (at 500 but not 100\u00a0mg\/kg) significantly mitigated all the measured physiological and biochemical indices. Sections from saline\u2010 and <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>\u2010treated rats showed apparently normal proximal tubules. However, kidneys of <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\u2010treated rats had a moderate degree of necrosis. This was markedly lessened when <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> was given simultaneously with <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> (500\u00a0mg\/kg). The concentration of platinum in the cortical tissues was not significantly altered by <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> treatment. The results suggested that <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> can ameliorate <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> nephrotoxicity in rats. Pending further pharmacological and toxicological studies, <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> may be considered a potentially useful nephroprotective agent in <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">ARI<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bcpt.12291","type":"journal-article","created":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T15:46:11Z","timestamp":1406043971000},"page":"62-68","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Renoprotective Effects of Gamma\u2010Aminobutyric Acid on Cisplatin\u2010induced Acute Renal Injury in Rats"],"prefix":"10.1111","volume":"116","author":[{"given":"Badreldin H.","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacy College of Medicine and Health Sciences Sultan Qaboos University Oman UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhail","family":"Al\u2013Salam","sequence":"additional","affiliation":[{"name":"Department of Pathology College of Medicine and Health Sciences UAE University Al Ain UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Al Za'abi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacy College of Medicine and Health Sciences Sultan Qaboos University Oman UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid A.","family":"Al Balushi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacy College of Medicine and Health Sciences Sultan Qaboos University Oman UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed S.","family":"AlMahruqi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacy College of Medicine and Health Sciences Sultan Qaboos University Oman UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somyia","family":"Beegam","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacy College of Medicine and Health Sciences Sultan Qaboos University Oman UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Intisar","family":"Al\u2010Lawatia","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacy College of Medicine and Health Sciences Sultan Qaboos University Oman UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa I.","family":"Waly","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition College of Agriculture Sultan Qaboos University Oman UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abderrahim","family":"Nemmar","sequence":"additional","affiliation":[{"name":"Department of Physiology College of Medicine and Health Sciences UAE University Al Ain UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.06.2043"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22508"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.620"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880010590964381"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31812dfe1e"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00055110"},{"key":"e_1_2_6_8_1","first-page":"1663","article-title":"Cisplatin and platinum drugs at the molecular level","volume":"10","author":"Boulikas T","year":"2003","journal-title":"Oncol Rep"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr195"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408444.2011.602662"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-012-0821-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins2112490"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2008.09.003"},{"key":"e_1_2_6_14_1","first-page":"18","article-title":"Antioxidants. 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