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In women in preterm labour, we compared the impact of terbutaline <jats:italic>versus<\/jats:italic> nifedipine on inhibition of uterine contractions, preterm birth, neonatal sepsis, intracranial haemorrhage or necrotizing enterocolitis, death or admission to a neonatal intensive care unit and maternal adverse reactions. We randomized 32 women to nifedipine and 34 to terbutaline. We found no difference between groups in tocolysis or preterm birth. No serious maternal adverse effects or serious neonatal adverse outcome occurred in either group. Less serious maternal adverse effects less common with terbutaline included flushing (2.94% <jats:italic>versus<\/jats:italic> 43.7%) and headache (5.9% <jats:italic>versus<\/jats:italic> 31.2%). The administration of terbutaline increased tremor (76.4% <jats:italic>versus<\/jats:italic> 0%), nausea (58.8% versus 9.4%) and dizziness (29.4% versus 6.25%). The total number of side effects, and the proportion of women experiencing one or more side effects, proved greater with terbutaline. In this study, terbutaline and nifedipine performed similarly in their tocolytic effects. Each drug has specific side effects, although overall, nifedipine was associated with fewer adverse effects.<\/jats:p>","DOI":"10.1111\/bcpt.12306","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T16:38:51Z","timestamp":1408639131000},"page":"244-250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Nifedipine <i>versus<\/i> Terbutaline, Tocolytic Effectiveness and Maternal and Neonatal Adverse Effects: A Randomized, Controlled Pilot Trial"],"prefix":"10.1111","volume":"116","author":[{"given":"Tania Regina","family":"Padovani","sequence":"first","affiliation":[{"name":"Pharmaceutical Sciences Post graduate Course University of Sorocaba, UNISO Sorocaba Brazil"},{"name":"Pontificia Universidade Cat\u00f3lica S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Guyatt","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciane Cruz","family":"Lopes","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Post graduate Course University of Sorocaba, UNISO Sorocaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.08.062554"},{"key":"e_1_2_9_3_1","first-page":"1404","article-title":"Preterm birth","volume":"2011","author":"Haas DM","year":"2011","journal-title":"Clin Evid (Online)"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.4.659"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.6.1290"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e6226"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31825af2f0"},{"key":"e_1_2_9_9_1","unstructured":"WHO.Tocolytics for preterm labour.http:\/\/apps.who.int\/rhl\/pregnancy_childbirth\/complications\/preterm_birth\/socom\/en\/(last accessed on 1 June 2014)."},{"key":"e_1_2_9_10_1","first-page":"CD007748","article-title":"Cyclo\u2010oxygenase (COX) inhibitors for preventing preterm labour","volume":"10","author":"Khanprakob T","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004352.pub2"},{"key":"e_1_2_9_12_1","first-page":"CD006395","article-title":"Prophylactic oral betamimetics for preventing preterm labour in singleton pregnancies","author":"Whitworth M","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1990.tb00733.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-011-0083-y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-200412000-00004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0004-8666.2003.00074.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999417"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1993.tb15171.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(98)00053-8"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.06.047"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)90679-6"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002255"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.11.038"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00182-8"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200105000-00053"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.03.001"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1262512"},{"key":"e_1_2_9_28_1","volume-title":"Tocolysis for Women in Preterm Labour","author":"(RCOG) RCoOaG","year":"2011"},{"key":"e_1_2_9_29_1","unstructured":"KLASCO RKE. 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