{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T01:40:21Z","timestamp":1784857221496,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:00:00Z","timestamp":1416268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007397","name":"Charles University in Prague","doi-asserted-by":"crossref","award":["P25\/1LF\/2 and P28\/1LF\/6"],"award-info":[{"award-number":["P25\/1LF\/2 and P28\/1LF\/6"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"crossref"}]},{"name":"EU Project \u00e2\u20ac\u017eMaterial- technical Research Base for the Diagnostics and Treatment of Environmentally-caused and Oncological Disorders and their Risks, in the General University Hospital in Prague","award":["CZ.2.16\/3.1.00\/24.12"],"award-info":[{"award-number":["CZ.2.16\/3.1.00\/24.12"]}]},{"DOI":"10.13039\/501100003243","name":"Ministry of Health of the Czech Republic","doi-asserted-by":"crossref","award":["12\/14\/NAP"],"award-info":[{"award-number":["12\/14\/NAP"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this article was to study the role of serum formate (S\u2010formate) in diagnosing methanol poisoning. A prospective study was undertaken of 38 patients from the Czech methanol mass poisoning in 2012 \u2013 median age 51 [interquartile range (IQR) 37\u201362] years with confirmed methanol poisoning. S\u2010formate was measured enzymatically. The receiver operating characteristics (ROC) curve was used to examine the predictive ability of S\u2010formate. Asymptomatic patients had median S\u2010formate of 1.9 (IQR 1.5\u20132.4) mmol\/L. The median S\u2010formate was 15.2 (IQR 13.9\u201317.6) mmol\/L in symptomatic subjects with visual disturbances, 15.4 (12.1\u201318.0) mmol\/L in subjects with dyspnoea and 15.7 (IQR 12.8\u201318.5) mmol\/L in comatose patients. The differences in serum formate concentrations in symptomatic patients depending on clinical features were not significant (all<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). Patients with long\u2010term visual sequelae of poisoning had median S\u2010formate of 16.1 (IQR 14.3\u201319.9) mmol\/L; with central nervous system (CNS) sequelae, patients had 15.9 (IQR 14.2\u201319.5) mmol\/L. In lethal cases, the median S\u2010formate was 15.2 (IQR 13.8\u201315.9) mmol\/L. The probability of a poor outcome (death or survival with sequelae) was higher than 90% in patients with S\u2010formate \u226517.5\u00a0mmol\/L, S\u2010lactate \u22657.0\u00a0mmol\/L and\/or pH &lt;6.87. The ROC analysis showed that the corresponding areas under the curve (AUC) were 0.64 (0.44\u20130.85 CI 95%) for S\u2010formate, 0.75 (0.56\u20130.93 CI 95%) for \u2018S\u2010formate+S\u2010lactate\u2019 and only 0.54 (0.38\u20130.69 CI 95%) for serum methanol, which is lower than for S\u2010formate (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The measurement of S\u2010formate is an important tool in the laboratory diagnostics and clinical management of acute methanol poisoning. S\u2010formate \u22653.7\u00a0mmol\/L can lead to the first clinical signs of visual toxicity, indicating haemodialysis. S\u2010formate \u226511\u201312\u00a0mmol\/L is associated with visual\/CNS sequelae and a lethal outcome.<\/jats:p>","DOI":"10.1111\/bcpt.12338","type":"journal-article","created":{"date-parts":[[2014,10,11]],"date-time":"2014-10-11T22:37:38Z","timestamp":1413067058000},"page":"445-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Is the Measurement of Serum Formate Concentration Useful in the Diagnostics of Acute Methanol Poisoning? A Prospective Study of 38 Patients"],"prefix":"10.1111","volume":"116","author":[{"given":"Sergey","family":"Zakharov","sequence":"first","affiliation":[{"name":"Toxicological Information Center Department of Occupational Medicine First Faculty of Medicine Charles University in Prague and General University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Kurcova","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Forensic Medicine First Faculty of Medicine Charles University in Prague and General University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Navratil","sequence":"additional","affiliation":[{"name":"Toxicological Information Center Department of Occupational Medicine First Faculty of Medicine Charles University in Prague and General University Hospital Prague Czech Republic"},{"name":"Department of Biomimetic Electrochemistry J. Heyrovsk\u00fd Institute of Physical Chemistry of the AS CR Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Salek","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Tomas Bata Regional Hospital in Zlin Zl\u00edn Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Komarc","sequence":"additional","affiliation":[{"name":"Institute of Biophysics and Informatics First Faculty of Medicine of Charles University in Prague General University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Pelclova","sequence":"additional","affiliation":[{"name":"Toxicological Information Center Department of Occupational Medicine First Faculty of Medicine Charles University in Prague and General University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650600956329"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2005.01521.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2014.974106"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-31802009000200011"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12047"},{"key":"e_1_2_9_7_1","first-page":"320","article-title":"Sequelae of methanol poisoning for cognition","volume":"77","author":"Bezdicek O","year":"2014","journal-title":"Cesk Slov Neurol N"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2521-0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.60"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2373-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0083-6729(08)00401-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016957"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12198"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1996.0302"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0026-895X(25)10468-9","article-title":"Studies on the role of folic\u2010acid and folate\u2010dependent enzymes in human methanol poisoning","volume":"31","author":"Johlin FC","year":"1987","journal-title":"Mol Pharmacol"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jab.2014.04.001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1983.tb03699.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-104-2-200"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90113-8"},{"key":"e_1_2_9_20_1","first-page":"235","article-title":"Methanol intoxication on magnetic resonance imaging","volume":"77","author":"Vaneckova M","year":"2014","journal-title":"Cesk Slov Neurol N"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/29.6.586"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9572(84)90011-X"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc7159"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051352"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12310"},{"key":"e_1_2_9_26_1","first-page":"668","volume-title":"Methods of Enzymatic Analysis","author":"Schaller KH","year":"1984"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/25.2.77"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1081\/CLT-120006745"},{"key":"e_1_2_9_29_1","article-title":"Fomepizole in treatment of acute methanol poisonings: experience from the Czech mass methanol outbreak 2012\u20132013","author":"Zakharov S","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91540-3"},{"key":"e_1_2_9_31_1","first-page":"605","volume-title":"Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose","author":"Jacobsen D","year":"2007"}],"container-title":["Basic &amp; 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