{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:34:59Z","timestamp":1792805699825,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T00:00:00Z","timestamp":1419811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005969","name":"University of Bologna","doi-asserted-by":"crossref","award":["RFO 2012"],"award-info":[{"award-number":["RFO 2012"]}],"id":[{"id":"10.13039\/501100005969","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was aimed to evaluate the possible alert signals of paraesthesia by local anaesthetics, focusing on those used in dentistry. A case\/non\u2010case study of spontaneous adverse events recorded in <jats:styled-content style=\"fixed-case\">FAERS<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">FDA<\/jats:styled-content> Adverse Event Reporting System) between 2004 and 2011 was performed. Cases were represented by the reports of reactions grouped under the term \u2018Paraesthesias and dysaesthesias\u2019 involving local anaesthetics (<jats:styled-content style=\"fixed-case\">ATC<\/jats:styled-content>: N01B*); non\u2010cases were all other reports of the same drugs. Reporting odds ratios (<jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content>) with the relevant 95% confidence intervals (95<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) were calculated. Alert signal was considered when number of cases &gt;3 and lower limit of <jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content> 95<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0&gt;\u00a01. To estimate the specificity of signals for dentistry, the analysis was restricted to the specific term \u201cOral Paraesthesia\u201d and to reports concerning dental practice. Overall, 528 reports of \u2018Paraesthesias and dysaesthesias\u2019 were retrieved, corresponding to 573 drug\u2013reaction pairs (247 lidocaine, 99 bupivacaine, 85 articaine, 30 prilocaine, 112 others). The signal was significant only for articaine (<jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content>=18.38; 95<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a013.95\u201324.21) and prilocaine (2.66; 1.82\u20133.90). The analysis of the specific term \u201cOral Paraesthesia\u201d retrieved 82 reports corresponding to 90 drug\u2013reaction pairs (37 articaine, 19 lidocaine, 14 prilocaine, 7 bupivacaine, 13 others) and confirmed the signal for articaine (58.77; 37.82\u201391.31) and prilocaine (8.73; 4.89\u201315.57). The analysis of reports concerning dental procedures retrieved a signal for articaine, both for any procedures (8.84; 2.79\u201327.97) and for non\u2010surgical ones (15.79; 1.87\u2013133.46). In conclusion, among local anaesthetics, only articaine and prilocaine generated a signal of paraesthesia, especially when used in dentistry.<\/jats:p>","DOI":"10.1111\/bcpt.12357","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T10:38:08Z","timestamp":1416911888000},"page":"52-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Paraesthesia after Local Anaesthetics: An Analysis of Reports to the <scp>FDA<\/scp> Adverse Event Reporting System"],"prefix":"10.1111","volume":"117","author":[{"given":"Carlo","family":"Piccinni","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences \u2013 Pharmacology Unit University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide B.","family":"Gissi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuro\u2010Muscular Sciences \u2013 Oral Sciences Unit University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gabusi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuro\u2010Muscular Sciences \u2013 Oral Sciences Unit University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Montebugnoli","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuro\u2010Muscular Sciences \u2013 Oral Sciences Unit University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Poluzzi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences \u2013 Pharmacology Unit University of Bologna Bologna 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