{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:04Z","timestamp":1787013904317,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Low\u2010dose acetylsalicylic acid (\n                    <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>\n                    ) is widely used as antithrombotic prophylaxis. Enteric\u2010coated\n                    <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>\n                    has been developed to decrease the risk of gastrointestinal side effects. The consequences of enteric coating on pharmacokinetics and antiplatelet effect of\n                    <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>\n                    have not systematically been assessed. This\n                    <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\n                    ini\n                    <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\n                    eview demonstrates that data from clinical trials indicate that enteric coating can reduce the antiplatelet effect of\n                    <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>\n                    compared to plain\n                    <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>\n                    . This is possibly due to decreased bioavailability of\n                    <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>\n                    caused by prolonged solvation and absorption of the enteric\u2010coated formulations. Therefore, low\u2010dose enteric\u2010coated\n                    <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>\n                    might not be bioequivalent to plain\n                    <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>\n                    , entailing the risk of insufficient cardiovascular prophylaxis.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.12362","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T18:45:55Z","timestamp":1417632355000},"page":"212-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Enteric Coating Can Lead to Reduced Antiplatelet Effect of Low\u2010Dose Acetylsalicylic Acid"],"prefix":"10.1111","volume":"116","author":[{"given":"Peter Fentz","family":"Haastrup","sequence":"first","affiliation":[{"name":"Research Unit of General Practice Department of Public Health University of Southern Denmark Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor","family":"Gr\u00f8nlykke","sequence":"additional","affiliation":[{"name":"Institute for Rational Pharmacotherapy Danish Health and Medicines Authority Kobenhavn Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorte Ejg","family":"Jarb\u00f8l","sequence":"additional","affiliation":[{"name":"Research Unit of General Practice Department of Public Health University of Southern Denmark Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60503-1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052717"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9041264"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00470.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00588.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2000.tb00404.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0306-5251.2001.01476.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.12.018"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.117283"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000231683.43347.ec"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03997.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.06.058"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043798-199604000-00013"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199121050-00006"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12637"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00324-0"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198510020-00004"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.72.6.1185"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198411083111902"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7329.71"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39430.529549.BE"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000013777.21160.07"}],"container-title":["Basic &amp; 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