{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:28:23Z","timestamp":1789399703148,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T00:00:00Z","timestamp":1422921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Concern about the renal safety of commonly used cardiovascular drugs with demonstrated clinical benefit appears to be an obstacle to their use in the elderly. The objective was to describe the relationship between cardiovascular drugs and chronic kidney disease (\n                    <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n                    ) in elderly individuals in the real\u2010life setting. This is an ancillary study of the prospective non\u2010interventional S.\n                    <jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content>\n                    (aged individuals) cohort. General physicians were free to prescribe any drug their patients needed. The participants were non\u2010institutionalized patients aged 65\u00a0years and older treated by their primary physician for either chronic pain or atrial fibrillation or type 2 diabetes mellitus. The estimated glomerular filtration rate (\n                    <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n                    ) derived from the\n                    <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">EPI<\/jats:styled-content>\n                    formula was determined at inclusion and every year during 2\u00a0years of follow\u2010up. This study comprised 2505 patients aged 77.8\u00a0\u00b1\u00a06.2\u00a0years. At inclusion, the factors associated with\n                    <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n                    (\n                    <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n                    \u00a0&lt;\u00a060\u00a0ml\/min\/1.73\u00a0m\n                    <jats:sup>2<\/jats:sup>\n                    ) in multivariate analysis were age, female gender, hypertension, heart failure, history of atherothrombotic disease and renin angiotensin system blockers, loop diuretics and calcium channel inhibitors. Introduction of each of these three drug classes during the follow\u2010up period led to only a small decrease in the\n                    <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n                    : \u22123.8\u00a0\u00b1\u00a012.7 (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0006), \u22122.2\u00a0\u00b1\u00a012.0 (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.003) and \u22121.0\u00a0\u00b1\u00a013.4\u00a0ml\/min.\/1.73\u00a0m\n                    <jats:sup>2<\/jats:sup>\n                    (\n                    <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>\n                    ), respectively. Only the introduction of loop diuretics was associated with\n                    <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n                    (\n                    <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                    1.91, 95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    : 1.25\u20132.90;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.002). Renal safety of cardiovascular drugs in the elderly appears acceptable and should not be a barrier to their use.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.12376","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T02:57:43Z","timestamp":1421377063000},"page":"137-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between Cardiovascular Drugs and Chronic Kidney Disease in Non\u2010Institutionalized Elderly Patients"],"prefix":"10.1111","volume":"117","author":[{"given":"Laurent","family":"Becquemont","sequence":"first","affiliation":[{"name":"Pharmacology Department Faculty of Medicine Paris\u2010Sud APHP Bic\u00eatre university Hospital University Paris\u2010Sud Le Kremlin Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Bauduceau","sequence":"additional","affiliation":[{"name":"Endocrinology Department B\u00e9gin hospital Saint\u2010Mand\u00e9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Benattar\u2010Zibi","sequence":"additional","affiliation":[{"name":"ORPEA\/CLINEA Puteaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Berrut","sequence":"additional","affiliation":[{"name":"Clinical Gerontology Nantes university hospital Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bertin","sequence":"additional","affiliation":[{"name":"Rheumatology Department Limoges University Hospital Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Bucher","sequence":"additional","affiliation":[{"name":"General Practice Department Faculty of Medicine Paris\u2010Sud University Paris\u2010Sud Le Kremlin\u2010Bic\u00eatre 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