{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:46:48Z","timestamp":1789530408205,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T00:00:00Z","timestamp":1424822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007397","name":"Charles University in Prague","doi-asserted-by":"crossref","award":["P25\/1LF\/2; P28\/1LF\/6"],"award-info":[{"award-number":["P25\/1LF\/2; P28\/1LF\/6"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"crossref"}]},{"name":"EU Project \u201eMaterial - technical Research Base for the Diagnostics and Treatment of Environmentally-caused and Oncological Disorders and their Risks, in the General University Hospital in Prague\u201d","award":["No. CZ.2.16\/3.1.00\/24.12"],"award-info":[{"award-number":["No. CZ.2.16\/3.1.00\/24.12"]}]},{"name":"General University Hospital in Prague","award":["RVO-VFN64165"],"award-info":[{"award-number":["RVO-VFN64165"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hydroxocobalamin is an effective first\u2010line antidote used mainly in monotherapy of cyanide poisonings, while the opinions are different on the effects of its combination with sodium thiosulfate. A 58\u2010year\u2010old male committed a suicide attempt by ingesting of 1200\u20131500\u00a0mg of potassium cyanide; he was unconscious for 1\u20131.5\u00a0min. after ingestion with the episode of generalized seizures. On admission to the <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>, the patient was acidotic (<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> 7.28; <jats:styled-content style=\"fixed-case\">HCO<\/jats:styled-content><jats:sub>3<\/jats:sub> 14.0\u00a0mmol\/L, base excess \u221212.7\u00a0mmol\/L, saturation O<jats:sub>2<\/jats:sub> 0.999) with high serum lactate (12.5\u00a0mmol\/L). Hydroxocobalamin was administered 1.5\u00a0hr after ingestion in two subsequent intravenous infusions at a total dose of 7.5\u00a0g. The infusion was followed by continuous intravenous administration of 1\u00a0mL\/hr\/kg of 10% sodium thiosulfate at a total dose of 12\u00a0g. No complications and adverse reactions were registered. Serum lactate decreased to 0.6\u00a0mmol\/L the same day, and arterial blood gases became normal (<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> 7.49; <jats:styled-content style=\"fixed-case\">HCO<\/jats:styled-content><jats:sub>3<\/jats:sub> 27.2\u00a0mmol\/L, base excess 2.2\u00a0mmol\/L, saturation O<jats:sub>2<\/jats:sub> 0.994). The follow\u2010up examination 5\u00a0months later revealed no damage of basal ganglia and cerebellum on magnetic resonance imaging. The neurological examination revealed no pathological findings. On the ocular coherence tomography, the retinal nerve fibres layer was normal. In visual evoked potentials, there was a normal evoked complex on the left eye and minor decrease in amplitude on the right eye. Combination of hydroxocobalamin and sodium thiosulfate can have a positive effect on the survival without long\u2010term neurological and visual sequelae in the cases of massive cyanide poisonings due to the possibility of a potentiation or synergism of hydroxocobalamin effects by sodium thiosulfate. This synergism can be explained by the different time\u2010points of action of two antidotes: the initial and immediate effect of hydroxocobalamin, followed by the delayed, but more persistent effect of sodium thiosulfate.<\/jats:p>","DOI":"10.1111\/bcpt.12387","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T11:41:00Z","timestamp":1422618060000},"page":"209-212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Successful Use of Hydroxocobalamin and Sodium Thiosulfate in Acute Cyanide Poisoning: A Case Report with Follow\u2010up"],"prefix":"10.1111","volume":"117","author":[{"given":"Sergey","family":"Zakharov","sequence":"first","affiliation":[{"name":"Department of Occupational Medicine Toxicological Information Centre First Faculty of Medicine Charles University in Prague and General University Hospital in Prague Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Vaneckova","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnostics First Faculty of Medicine Charles University in Prague and General University Hospital in Prague Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdenek","family":"Seidl","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnostics First Faculty of Medicine Charles University in Prague and General University Hospital in Prague Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Diblik","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology First Faculty of Medicine Charles University in Prague and General University Hospital in Prague Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Kuthan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology First Faculty of Medicine Charles University in Prague and General University Hospital in Prague Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine Toxicological Information Centre First Faculty of Medicine Charles University in Prague and General University Hospital in Prague Prague Czech Republic"},{"name":"National Institute of Public Health Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Navratil","sequence":"additional","affiliation":[{"name":"Department of Biomimetic Electrochemistry J. 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